How does electroconvulsive therapy work?: Theories on its mechanism

Tom G Bolwig

How does electroconvulsive therapy work? Theories on its mechanism

Tom G Bolwig

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

130 Citationer (Scopus)

Abstract

This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experimental animals given electroconvulsive seizures. Presently, the endocrine theory has the strongest foundation to explain the working mechanism of ECT.

Originalsprog	Engelsk
Tidsskrift	Canadian Journal of Psychiatry
Vol/bind	56
Udgave nummer	1
Sider (fra-til)	13-8
Antal sider	6
ISSN	0706-7437
Status	Udgivet - 2011

Citationsformater

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AB - This article reviews 3 current theories of electroconvulsive therapy (ECT). One theory points to generalized seizures as essential for the therapeutic efficacy of ECT. Another theory highlights the normalization of neuroendocrine dysfunction in melancholic depression as a result of ECT. A third theory is based on recent findings of increased hippocampal neurogenesis and synaptogenesis in experimental animals given electroconvulsive seizures. Presently, the endocrine theory has the strongest foundation to explain the working mechanism of ECT.

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