TY - JOUR
T1 - Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer
AU - Keijzers, Guido
AU - Bakula, Daniela
AU - Petr, Michael Angelo
AU - Madsen, Nils Gedsig Kirkelund
AU - Teklu, Amanuel
AU - Mkrtchyan, Garik
AU - Osborne, Brenna
AU - Scheibye-Knudsen, Morten
PY - 2019
Y1 - 2019
N2 - Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.
AB - Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.
KW - DNA repair
KW - Double strand break repair
KW - EXO1
KW - Exonuclease 1
KW - Mismatch repair
KW - MMR
KW - NER
KW - Nucleotide excision repair
KW - Strand displacements
KW - TLS
KW - Translesion DNA synthesis
U2 - 10.3390/ijms20010074
DO - 10.3390/ijms20010074
M3 - Review
C2 - 30585186
AN - SCOPUS:85059116556
VL - 20
JO - International Journal of Molecular Sciences (Online)
JF - International Journal of Molecular Sciences (Online)
SN - 1661-6596
IS - 1
M1 - 74
ER -