Human exonuclease 1 (EXO1) regulatory functions in DNA replication with putative roles in cancer

Guido Keijzers*, Daniela Bakula, Michael Angelo Petr, Nils Gedsig Kirkelund Madsen, Amanuel Teklu, Garik Mkrtchyan, Brenna Osborne, Morten Scheibye-Knudsen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

43 Citationer (Scopus)
194 Downloads (Pure)

Abstract

Human exonuclease 1 (EXO1), a 5′→3′ exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.

OriginalsprogEngelsk
Artikelnummer74
TidsskriftInternational Journal of Molecular Sciences
Vol/bind20
Udgave nummer1
Antal sider15
ISSN1661-6596
DOI
StatusUdgivet - 2019

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