Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Haematology |
| Vol/bind | 64 |
| Udgave nummer | 6 |
| Sider (fra-til) | 368-375 |
| Antal sider | 7 |
| ISSN | 0902-4441 |
| Status | Udgivet - 2000 |
Bibliografisk note
Keywords: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; DNA, Viral; Denmark; Doxorubicin; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; In Situ Hybridization; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Polymerase Chain Reaction; Prednisone; RNA, Viral; Retrospective Studies; Treatment Outcome; VincristineCitationsformater
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Human immunodeficiency virus-associated malignant lymphoma in eastern Denmark diagnosed from 1990-1996: clinical features, histopathology, and association with Epstein-Barr virus and human herpesvirus-8. / Hansen, P B; Penkowa, M; Kirk, O; Skinhøj, P; Pedersen, C; Lisse, I; Kiss, K; Zhou, X; Hamilton-Dutoit, S J.
I: European Journal of Haematology, Bind 64, Nr. 6, 2000, s. 368-375.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Human immunodeficiency virus-associated malignant lymphoma in eastern Denmark diagnosed from 1990-1996: clinical features, histopathology, and association with Epstein-Barr virus and human herpesvirus-8
AU - Hansen, P B
AU - Penkowa, M
AU - Kirk, O
AU - Skinhøj, P
AU - Pedersen, C
AU - Lisse, I
AU - Kiss, K
AU - Zhou, X
AU - Hamilton-Dutoit, S J
N1 - Keywords: Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; DNA, Viral; Denmark; Doxorubicin; Herpesvirus 4, Human; Herpesvirus 8, Human; Humans; In Situ Hybridization; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Polymerase Chain Reaction; Prednisone; RNA, Viral; Retrospective Studies; Treatment Outcome; Vincristine
PY - 2000
Y1 - 2000
N2 - The clinicopathological features of human immunodeficiency virus (HIV)-associated lymphoma were investigated in a retrospective study of 85 adult patients in eastern Denmark diagnosed during the period 1990-1996. The possible pathogenetic role of Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) in these tumours was also studied. Seventy patients (82%) presented with extranodal disease and 26 (31%) had CNS involvement at diagnosis. Diffuse large cell B-cell lymphoma was the most frequent histological subtype, comprising 65 of 79 cases available for microscopic re-evaluation (82%) and including 20 of 23 evaluable patients with CNS lymphoma (87%). EBV RNA was demonstrated by in situ hybridization in 51 of 65 evaluable tumours (79%) and in 14 of 16 cases (88%) with CNS-lymphoma. Three cases showed a T-cell phenotype. The presence of HHV-8 DNA was analysed by PCR in 32 cases. A strong band consistent with tumour cell infection was detected in only one case, weaker bands being seen in 4 cases. None of these patients had primary effusion lymphomas. In conclusion, Danish AIDS-related lymphomas are of predominantly high-grade B-cell type with extranodal localization and atypical presentation. Our results provide further evidence that EBV plays a major role in the pathogenesis of large cell AIDS-related lymphoma, whereas HHV-8 does not appear to contribute significantly to the development of solid lymphomas in this group of patients.
AB - The clinicopathological features of human immunodeficiency virus (HIV)-associated lymphoma were investigated in a retrospective study of 85 adult patients in eastern Denmark diagnosed during the period 1990-1996. The possible pathogenetic role of Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8) in these tumours was also studied. Seventy patients (82%) presented with extranodal disease and 26 (31%) had CNS involvement at diagnosis. Diffuse large cell B-cell lymphoma was the most frequent histological subtype, comprising 65 of 79 cases available for microscopic re-evaluation (82%) and including 20 of 23 evaluable patients with CNS lymphoma (87%). EBV RNA was demonstrated by in situ hybridization in 51 of 65 evaluable tumours (79%) and in 14 of 16 cases (88%) with CNS-lymphoma. Three cases showed a T-cell phenotype. The presence of HHV-8 DNA was analysed by PCR in 32 cases. A strong band consistent with tumour cell infection was detected in only one case, weaker bands being seen in 4 cases. None of these patients had primary effusion lymphomas. In conclusion, Danish AIDS-related lymphomas are of predominantly high-grade B-cell type with extranodal localization and atypical presentation. Our results provide further evidence that EBV plays a major role in the pathogenesis of large cell AIDS-related lymphoma, whereas HHV-8 does not appear to contribute significantly to the development of solid lymphomas in this group of patients.
M3 - Journal article
C2 - 10901590
VL - 64
SP - 368
EP - 375
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 6
ER -