TY - JOUR
T1 - Human papillomavirus triage of women with persistent borderline or mildly dyskaryotic smears: Comparison of costs and side effects of three alternative strategies
AU - Rebolj, Matejka
AU - Bais, Aagje G
AU - van Ballegooijen, Marjolein
AU - Boer, Rob
AU - Meerding, Willem-Jan
AU - Helmerhorst, Theo J M
AU - Habbema, J Dik F
N1 - Keywords: Cervical Intraepithelial Neoplasia; Colposcopy; Female; Humans; Mass Screening; Papillomaviridae; Papillomavirus Infections; Referral and Consultation; Reproducibility of Results; Time Factors; Triage; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vaginal Smears
PY - 2007
Y1 - 2007
N2 - The conventional direct referral to colposcopy of persistent borderline or mildly dyskaryotic (BMD) smears in cervical cancer screening leads to considerable unnecessary referrals and associated anxiety and costs. This may be improved by including testing for oncogenic human papillomavirus (HPV) in the triage. We assessed costs and side effects (referrals, treatments and time in follow-up) for 3 possible HPV triage strategies (immediate HPV testing, a 6-month delay in HPV testing, a 2-stage combination of both) and compared them with the conventional strategy. The assessments are based on recent Dutch data from various national databases and trials. We estimated that the referral rate could be reduced by 49, 58 and 58% with immediate, delayed and 2-stage HPV testing, respectively. As a consequence, the average length of follow-up, as well as average costs, also decrease. Therefore, we advocate including HPV testing before referring to colposcopy. Among the 3 HPV strategies, analysis of additional aspects favors implementation of immediate HPV testing.
AB - The conventional direct referral to colposcopy of persistent borderline or mildly dyskaryotic (BMD) smears in cervical cancer screening leads to considerable unnecessary referrals and associated anxiety and costs. This may be improved by including testing for oncogenic human papillomavirus (HPV) in the triage. We assessed costs and side effects (referrals, treatments and time in follow-up) for 3 possible HPV triage strategies (immediate HPV testing, a 6-month delay in HPV testing, a 2-stage combination of both) and compared them with the conventional strategy. The assessments are based on recent Dutch data from various national databases and trials. We estimated that the referral rate could be reduced by 49, 58 and 58% with immediate, delayed and 2-stage HPV testing, respectively. As a consequence, the average length of follow-up, as well as average costs, also decrease. Therefore, we advocate including HPV testing before referring to colposcopy. Among the 3 HPV strategies, analysis of additional aspects favors implementation of immediate HPV testing.
U2 - 10.1002/ijc.22838
DO - 10.1002/ijc.22838
M3 - Journal article
C2 - 17565745
SN - 0020-7136
VL - 121
SP - 1529
EP - 1535
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 7
ER -