Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

Anna Cecilia Jørgensen; Anette Seo Torstenson

doi:10.1080/10837450801949384

Humid storage conditions increase the dissolution rate of diazepam from solid dispersions prepared by melt agglomeration

Anna Cecilia Jørgensen, Anette Seo Torstenson

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

Abstract

The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

Originalsprog	Engelsk
Tidsskrift	Pharmaceutical Development and Technology
Vol/bind	13
Udgave nummer	3
Sider (fra-til)	187-95
Antal sider	8
ISSN	1083-7450
DOI	https://doi.org/10.1080/10837450801949384
Status	Udgivet - 2008

Bibliografisk note

Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction

Emneord

Det tidligere Farmaceutiske Fakultet

Adgang til dokumentet

10.1080/10837450801949384

Citationsformater

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abstract = "The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.",

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note = "Keywords: Calorimetry, Differential Scanning; Diazepam; Drug Storage; Humidity; Hypnotics and Sedatives; Kinetics; Microscopy, Electron, Scanning; Particle Size; Solubility; Spectroscopy, Near-Infrared; Thermogravimetry; Water; X-Ray Diffraction",

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AU - Jørgensen, Anna Cecilia

AU - Torstenson, Anette Seo

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PY - 2008

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N2 - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

AB - The purpose of this study is to investigate the effect of cooling mode and storage conditions on the dissolution rate of a solid dispersion prepared by melt agglomeration. The aim has been to relate this effect to the solid state properties of the agglomerates. The cooling mode had an effect on the dissolution rate, probably due to several factors such as the morphology of the agglomerates and crystallinity of the carrier. The dissolution increased with increasing temperature and relative humidity which increased the amount of water sorbed in the carrier. The processing and storage conditions were shown to have a complex interplay.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1080/10837450801949384

DO - 10.1080/10837450801949384

M3 - Journal article

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SN - 1083-7450

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SP - 187

EP - 195

JO - Pharmaceutical Development and Technology

JF - Pharmaceutical Development and Technology

IS - 3

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