Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Internal Medicine |
| Vol/bind | 20 |
| Udgave nummer | 2 |
| Sider (fra-til) | 139-44 |
| Antal sider | 6 |
| ISSN | 0953-6205 |
| DOI | |
| Status | Udgivet - 2008 |
Bibliografisk note
Keywords: Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Cholesterol; Coronary Disease; Denmark; Female; Humans; Hypercholesterolemia; Incidence; Male; Middle Aged; Risk FactorsAdgang til dokumentet
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I: European Journal of Internal Medicine, Bind 20, Nr. 2, 2008, s. 139-44.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Hypercholesterolaemia and risk of coronary heart disease in the elderly: impact of age: the Copenhagen City Heart Study
AU - Iversen, Allan
AU - Jensen, Jan Skov
AU - Scharling, Henrik
AU - Schnohr, Peter
N1 - Keywords: Adult; Age Distribution; Aged; Aged, 80 and over; Aging; Cholesterol; Coronary Disease; Denmark; Female; Humans; Hypercholesterolemia; Incidence; Male; Middle Aged; Risk Factors
PY - 2008
Y1 - 2008
N2 - BACKGROUND: Population and interventional studies have shown that high plasma-cholesterol is a risk factor of coronary heart disease (CHD). However, in most of the studies elderly people were excluded. AIM: This paper assesses whether the effect of total plasma-cholesterol on the risk of incident CHD decreases with age in a healthy population. METHODS: Within the Copenhagen City Heart Study in 1981-1983, 4647 men and 5829 women, aged 40-93 years, underwent a cardiovascular health examination including measurement of plasma-cholesterol. The cohort was followed with respect to incident CHD until 1994, i.e. before statins were introduced in Denmark. RESULTS: In people below 60 years of age plasma-cholesterol levels on 5-6; 6-8; and >8 mmol/L were associated with relative risks of CHD on 2.0 (95% confidence interval (CI) 1.2-3.2, P=0.004); 3.1 (CI 2.0-5.0, P<0.001); and 5.1 (CI 2.8-9.3, P<0.001), respectively (reference group: plasma-cholesterol <5 mmol/L). In people aged 60-70 years a plasma-cholesterol level on 5-6 mmol/L was not associated with increased risk, whereas plasma-cholesterol on 6-8 mmol/L and >8 mmol/L was associated with relative risks on 1.3 (CI 1.0-1.8, P=0.03), and 2.3 (CI 1.6-3.4, P<0.001), respectively. In people aged 70-80 years only plasma-cholesterol >8 mmol/L conferred increased relative risk on 1.6 (CI 1.2-2.4, P=0.007). In people above 80 years of age increased plasma-cholesterol was not associated with increased risk of incident CHD. CONCLUSION: The risk of incident CHD associated with high plasma-cholesterol declines with age. This finding should be considered in future recommendations of plasma-cholesterol levels in elderly people without atherosclerotic cardiovascular disease.
AB - BACKGROUND: Population and interventional studies have shown that high plasma-cholesterol is a risk factor of coronary heart disease (CHD). However, in most of the studies elderly people were excluded. AIM: This paper assesses whether the effect of total plasma-cholesterol on the risk of incident CHD decreases with age in a healthy population. METHODS: Within the Copenhagen City Heart Study in 1981-1983, 4647 men and 5829 women, aged 40-93 years, underwent a cardiovascular health examination including measurement of plasma-cholesterol. The cohort was followed with respect to incident CHD until 1994, i.e. before statins were introduced in Denmark. RESULTS: In people below 60 years of age plasma-cholesterol levels on 5-6; 6-8; and >8 mmol/L were associated with relative risks of CHD on 2.0 (95% confidence interval (CI) 1.2-3.2, P=0.004); 3.1 (CI 2.0-5.0, P<0.001); and 5.1 (CI 2.8-9.3, P<0.001), respectively (reference group: plasma-cholesterol <5 mmol/L). In people aged 60-70 years a plasma-cholesterol level on 5-6 mmol/L was not associated with increased risk, whereas plasma-cholesterol on 6-8 mmol/L and >8 mmol/L was associated with relative risks on 1.3 (CI 1.0-1.8, P=0.03), and 2.3 (CI 1.6-3.4, P<0.001), respectively. In people aged 70-80 years only plasma-cholesterol >8 mmol/L conferred increased relative risk on 1.6 (CI 1.2-2.4, P=0.007). In people above 80 years of age increased plasma-cholesterol was not associated with increased risk of incident CHD. CONCLUSION: The risk of incident CHD associated with high plasma-cholesterol declines with age. This finding should be considered in future recommendations of plasma-cholesterol levels in elderly people without atherosclerotic cardiovascular disease.
U2 - 10.1016/j.ejim.2008.06.003
DO - 10.1016/j.ejim.2008.06.003
M3 - Journal article
C2 - 19327601
SN - 0953-6205
VL - 20
SP - 139
EP - 144
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
IS - 2
ER -