TY - UNPB
T1 - Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity
AU - Stinson, Sara E.
AU - Huang, Yun
AU - Thielemann, Roman
AU - Stankevic, Evelina
AU - Lund, Morten A.V.
AU - Holm, Louise A.
AU - Fonvig, Cilius E.
AU - Juel, Helene Bæk
AU - Borisevich, Dmitrii
AU - Thiele, Maja
AU - Krag, Aleksander
AU - Ängquist, Lars
AU - Sørensen, Thorkild I.A.
AU - Pedersen, Oluf
AU - Christiansen, Michael
AU - Holm, Jens-Christian
AU - Hansen, Torben
PY - 2025/2/25
Y1 - 2025/2/25
N2 - Pediatric obesity is associated with multi-organ inflammation and an increased risk of cardiometabolic disease. To identify novel biomarkers of early-onset obesity-related cardiometabolic risk, we performed targeted proteomics, analyzing 149 proteins related to inflammation and cardiovascular disease in a cross-sectional sample of 2,377 children and adolescents with overweight/obesity and 1,647 with normal weight. In addition, we analyzed 64 circulating inflammation-related proteins in 184 children and adolescents, who participated in a 1-year family-based obesity management program. We identified a three plasma protein panel (CDCP1, FGF21 and HAOX1) that improved prediction of hepatic steatosis, compared with the predictive value of liver enzymes alone. In the prospective trial, we found that the non-pharmacological intervention induced a decline in circulating inflammatory cytokine levels, some of which were linked to improvements in cardiometabolic phenotypes. Our results may suggest that circulating proteomic signatures may mediate the associations between pediatric obesity and cardiometabolic risk.
AB - Pediatric obesity is associated with multi-organ inflammation and an increased risk of cardiometabolic disease. To identify novel biomarkers of early-onset obesity-related cardiometabolic risk, we performed targeted proteomics, analyzing 149 proteins related to inflammation and cardiovascular disease in a cross-sectional sample of 2,377 children and adolescents with overweight/obesity and 1,647 with normal weight. In addition, we analyzed 64 circulating inflammation-related proteins in 184 children and adolescents, who participated in a 1-year family-based obesity management program. We identified a three plasma protein panel (CDCP1, FGF21 and HAOX1) that improved prediction of hepatic steatosis, compared with the predictive value of liver enzymes alone. In the prospective trial, we found that the non-pharmacological intervention induced a decline in circulating inflammatory cytokine levels, some of which were linked to improvements in cardiometabolic phenotypes. Our results may suggest that circulating proteomic signatures may mediate the associations between pediatric obesity and cardiometabolic risk.
U2 - 10.1101/2025.02.25.25322850
DO - 10.1101/2025.02.25.25322850
M3 - Preprint
BT - Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity
PB - medRxiv
ER -