TY - JOUR
T1 - Identifying Gene-Environment Interactions in Schizophrenia
T2 - Contemporary Challenges for Integrated, Large-scale Investigations
AU - van Os, Jim
AU - Rutten, Bart P
AU - Myin-Germeys, Inez
AU - Delespaul, Philippe
AU - Viechtbauer, Wolfgang
AU - van Zelst, Catherine
AU - Bruggeman, Richard
AU - Reininghaus, Ulrich
AU - Morgan, Craig
AU - Murray, Robin M
AU - Di Forti, Marta
AU - McGuire, Philip
AU - Valmaggia, Lucia R
AU - Kempton, Matthew J
AU - Gayer-Anderson, Charlotte
AU - Hubbard, Kathryn
AU - Beards, Stephanie
AU - Stilo, Simona A
AU - Onyejiaka, Adanna
AU - Bourque, Francois
AU - Modinos, Gemma
AU - Tognin, Stefania
AU - Calem, Maria
AU - O'Donovan, Michael C
AU - Owen, Michael J
AU - Holmans, Peter
AU - Williams, Nigel
AU - Craddock, Nicholas
AU - Richards, Alexander
AU - Humphreys, Isla
AU - Meyer-Lindenberg, Andreas
AU - Leweke, F Markus
AU - Tost, Heike
AU - Akdeniz, Ceren
AU - Rohleder, Cathrin
AU - Bumb, J Malte
AU - Schwarz, Emanuel
AU - Alptekin, Köksal
AU - Üçok, Alp
AU - Saka, Meram Can
AU - Atbaşoğlu, E Cem
AU - Gülöksüz, Sinan
AU - Gumus-Akay, Guvem
AU - Cihan, Burçin
AU - Karadağ, Hasan
AU - Soygür, Haldan
AU - Cankurtaran, Eylem Şahin
AU - Ulusoy, Semra
AU - Akdede, Berna
AU - Nordentoft, Merete
AU - European Network of National Networks studying Gene-Environment Interactions in Schizophrenia (EU-GEI)
N1 - © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: [email protected].
PY - 2014/7
Y1 - 2014/7
N2 - Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
AB - Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
KW - Gene-Environment Interaction
KW - Genetic Predisposition to Disease
KW - Humans
KW - Schizophrenia
KW - Schizophrenic Psychology
KW - Social Environment
U2 - 10.1093/schbul/sbu069
DO - 10.1093/schbul/sbu069
M3 - Journal article
C2 - 24860087
VL - 40
SP - 729
EP - 736
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
SN - 0586-7614
IS - 4
ER -