TY - JOUR
T1 - IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
AU - Lefranc, Marie-Paule
AU - Pommié, Christelle
AU - Kaas, Quentin
AU - Duprat, Elodie
AU - Bosc, Nathalie
AU - Guiraudou, Delphine
AU - Jean, Christelle
AU - Ruiz, Manuel
AU - Da Piédade, Isabelle
AU - Rouard, Mathieu
AU - Foulquier, Elodie
AU - Thouvenin, Valérie
AU - Lefranc, Gérard
N1 - Keywords: Amino Acid Sequence; Humans; Immunoglobulins; Internet; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Antigen, T-Cell; Sequence Analysis, DNA; Sequence Analysis, Protein; Terminology as Topic
PY - 2005
Y1 - 2005
N2 - IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species.
AB - IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species.
U2 - 10.1016/j.dci.2004.07.003
DO - 10.1016/j.dci.2004.07.003
M3 - Journal article
C2 - 15572068
SN - 0145-305X
VL - 29
SP - 185
EP - 203
JO - Developmental & Comparative Immunology
JF - Developmental & Comparative Immunology
IS - 3
ER -