Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | European Journal of Immunology |
| Vol/bind | 21 |
| Udgave nummer | 4 |
| Sider (fra-til) | 1019-25 |
| Antal sider | 6 |
| ISSN | 0014-2980 |
| DOI | |
| Status | Udgivet - 1991 |
Bibliografisk note
Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Humans; Interferon-gamma; Longitudinal Studies; Lymphocyte Activation; Malaria; Plasmodium falciparum; Prospective StudiesAdgang til dokumentet
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I: European Journal of Immunology, Bind 21, Nr. 4, 1991, s. 1019-25.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Immune response to soluble exoantigens of Plasmodium falciparum may contribute to both pathogenesis and protection in clinical malaria: evidence from a longitudinal, prospective study of semi-immune African children
AU - Riley, E M
AU - Jakobsen, P H
AU - Allen, S J
AU - Wheeler, J G
AU - Bennett, S
AU - Jepsen, S
AU - Greenwood, B M
N1 - Keywords: Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Humans; Interferon-gamma; Longitudinal Studies; Lymphocyte Activation; Malaria; Plasmodium falciparum; Prospective Studies
PY - 1991
Y1 - 1991
N2 - Some soluble exoantigens of Plasmodium have lipopolysaccharide (LPS)-like properties and are believed to contribute to the pathogenesis of acute malaria. We have studied cellular and humoral immune responses to several purified exoantigens of Plasmodium falciparum in a cohort of children and compared these responses with their subsequent susceptibility to malaria infection and clinical disease. We found no evidence that either lymphoproliferative or interferon-gamma (IFN-gamma) responses to these antigens were associated with protective immunity. On the contrary, children whose cells produced IFN-gamma after in vitro activation with one of the soluble antigens (Ag7) were more likely to experience clinical manifestations of malaria infection (fever and malaise) than were children whose cells did not produce IFN-gamma. It is possible that exoantigen-induced IFN-gamma may exacerbate the LPS-like effects of these antigens. However, serum antibodies to another antigen (Ag2) were more prevalent in children with asymptomatic infections or low parasitemia than in children with fever and higher parasitemia (confirmed clinical malaria), suggesting that these antibodies may contribute to the development of protective immunity.
AB - Some soluble exoantigens of Plasmodium have lipopolysaccharide (LPS)-like properties and are believed to contribute to the pathogenesis of acute malaria. We have studied cellular and humoral immune responses to several purified exoantigens of Plasmodium falciparum in a cohort of children and compared these responses with their subsequent susceptibility to malaria infection and clinical disease. We found no evidence that either lymphoproliferative or interferon-gamma (IFN-gamma) responses to these antigens were associated with protective immunity. On the contrary, children whose cells produced IFN-gamma after in vitro activation with one of the soluble antigens (Ag7) were more likely to experience clinical manifestations of malaria infection (fever and malaise) than were children whose cells did not produce IFN-gamma. It is possible that exoantigen-induced IFN-gamma may exacerbate the LPS-like effects of these antigens. However, serum antibodies to another antigen (Ag2) were more prevalent in children with asymptomatic infections or low parasitemia than in children with fever and higher parasitemia (confirmed clinical malaria), suggesting that these antibodies may contribute to the development of protective immunity.
U2 - 10.1002/eji.1830210424
DO - 10.1002/eji.1830210424
M3 - Journal article
C2 - 1902173
SN - 0014-2980
VL - 21
SP - 1019
EP - 1025
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 4
ER -