Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems

S. Hook; T. Rades

doi:10.1007/978-1-4614-5070-2_12

Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems

S. Hook^*, T. Rades

^*Corresponding author af dette arbejde

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

5 Citationer (Scopus)

Abstract

Immune stimulating complexes (ISCOMs) belong to the group of particulate vaccine delivery systems. These particles have received considerable attention in the field of vaccine delivery systems, especially for subunit vaccines. ISCOMs have a spherical, open and cage-like structure and a particle size of around 40nm. They contain an adjuvant (Quil A or QS 21) and an antigen incorporated into or associated with their colloidal structure, making ISCOMs particulate antigen delivery systems which allow co-delivery of antigen and adjuvant. In this chapter we initially describe the components, microstructures and preparation methods of ISCOMs followed by their mechanism of immune stimulation and their use as vaccines.

Originalsprog	Engelsk
Titel	Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines
Antal sider	29
Forlag	Springer New York
Publikationsdato	1 jan. 2013
Sider	233-261
ISBN (Trykt)	9781461450696
ISBN (Elektronisk)	9781461450702
DOI	https://doi.org/10.1007/978-1-4614-5070-2_12
Status	Udgivet - 1 jan. 2013

Bibliografisk note

Publisher Copyright:
© Springer Science+Business Media New York 2013. All rights reserved.

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10.1007/978-1-4614-5070-2_12

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Link to publication in Scopus

Citationsformater

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