Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Infection and Immunity |
| Vol/bind | 75 |
| Udgave nummer | 5 |
| Sider (fra-til) | 2415-20 |
| Antal sider | 5 |
| ISSN | 0019-9567 |
| DOI | |
| Status | Udgivet - 2007 |
Bibliografisk note
Keywords: Adolescent; Adult; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Logistic Models; Malaria, Falciparum; Prevalence; Protozoan Proteins; Recombinant Proteins; TanzaniaAdgang til dokumentet
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Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria. / Magistrado, Pamela A; Lusingu, John; Vestergaard, Lasse S; Lemnge, Martha; Lavstsen, Thomas; Turner, Louise; Hviid, Lars; Jensen, Anja T R; Theander, Thor G.
I: Infection and Immunity, Bind 75, Nr. 5, 2007, s. 2415-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria
AU - Magistrado, Pamela A
AU - Lusingu, John
AU - Vestergaard, Lasse S
AU - Lemnge, Martha
AU - Lavstsen, Thomas
AU - Turner, Louise
AU - Hviid, Lars
AU - Jensen, Anja T R
AU - Theander, Thor G
N1 - Keywords: Adolescent; Adult; Animals; Antibodies, Protozoan; Child; Child, Preschool; Humans; Immunoglobulin G; Logistic Models; Malaria, Falciparum; Prevalence; Protozoan Proteins; Recombinant Proteins; Tanzania
PY - 2007
Y1 - 2007
N2 - Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood cells play a major role in the pathogenesis of malaria and are key targets for acquired immunity. The best-characterized VSA belong to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. In areas where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A PfEMP1. PF11_0008 has previously been found to be highly transcribed in a nonimmune Dutch volunteer experimentally infected with NF54 parasites. A high proportion of the Tanzanian donors had antibodies against recombinant PF11_0008 domains, and in children who were 4 to 9 years old the presence of antibodies to the PF11_0008 CIDR2beta domain was associated with reduced numbers of malaria episodes. These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes.
AB - Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood cells play a major role in the pathogenesis of malaria and are key targets for acquired immunity. The best-characterized VSA belong to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. In areas where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A PfEMP1. PF11_0008 has previously been found to be highly transcribed in a nonimmune Dutch volunteer experimentally infected with NF54 parasites. A high proportion of the Tanzanian donors had antibodies against recombinant PF11_0008 domains, and in children who were 4 to 9 years old the presence of antibodies to the PF11_0008 CIDR2beta domain was associated with reduced numbers of malaria episodes. These results indicate that homologues of PF11_0008 are present in P. falciparum field isolates and suggest that PF11_0008 CIDR2beta-reactive antibodies might be involved in protection against malaria episodes.
U2 - 10.1128/IAI.00951-06
DO - 10.1128/IAI.00951-06
M3 - Journal article
C2 - 17283085
VL - 75
SP - 2415
EP - 2420
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 5
ER -