Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children

P H Jakobsen; M M Lemnge; Y A Abu-Zeid; H A Msangeni; F M Salum; J I Mhina; J A Akida; A S Ruta; A M Ronn; P M Heegaard; R G Ridley; I C Bygbjerg

Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children

P H Jakobsen, M M Lemnge, Y A Abu-Zeid, H A Msangeni, F M Salum, J I Mhina, J A Akida, A S Ruta, A M Ronn, P M Heegaard, R G Ridley, I C Bygbjerg

Centre for Medical Parasitology

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

17 Citationer (Scopus)

Abstract

Udgivelsesdato: 1996-Dec

Originalsprog	Engelsk
Tidsskrift	American Journal of Tropical Medicine and Hygiene
Vol/bind	55
Udgave nummer	6
Sider (fra-til)	642-6
Antal sider	4
ISSN	0002-9637
Status	Udgivet - 1996

Bibliografisk note

Keywords: Age Factors; Analysis of Variance; Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G; Immunoglobulin M; Infant; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; Prevalence; Protozoan Proteins; Recombinant Proteins; Tanzania

Citationsformater

Jakobsen, P. H., Lemnge, M. M., Abu-Zeid, Y. A., Msangeni, H. A., Salum, F. M., Mhina, J. I., Akida, J. A., Ruta, A. S., Ronn, A. M., Heegaard, P. M., Ridley, R. G., & Bygbjerg, I. C. (1996). Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children. American Journal of Tropical Medicine and Hygiene, 55(6), 642-6.

Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children. / Jakobsen, P H; Lemnge, M M; Abu-Zeid, Y A; Msangeni, H A; Salum, F M; Mhina, J I; Akida, J A; Ruta, A S; Ronn, A M; Heegaard, P M; Ridley, R G; Bygbjerg, I C.

I: American Journal of Tropical Medicine and Hygiene, Bind 55, Nr. 6, 1996, s. 642-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Jakobsen, PH, Lemnge, MM, Abu-Zeid, YA, Msangeni, HA, Salum, FM, Mhina, JI, Akida, JA, Ruta, AS, Ronn, AM, Heegaard, PM, Ridley, RG & Bygbjerg, IC 1996, 'Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children', American Journal of Tropical Medicine and Hygiene, bind 55, nr. 6, s. 642-6.

Jakobsen, P H ; Lemnge, M M ; Abu-Zeid, Y A ; Msangeni, H A ; Salum, F M ; Mhina, J I ; Akida, J A ; Ruta, A S ; Ronn, A M ; Heegaard, P M ; Ridley, R G ; Bygbjerg, I C. / Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children. I: American Journal of Tropical Medicine and Hygiene. 1996 ; Bind 55, Nr. 6. s. 642-6.

@article{a32e5fd0e61511ddbf70000ea68e967b,

title = "Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children",

abstract = "In the Muheza region of Tanzania, an area with holoendemic malaria, the proportion of responders with IgG enzyme-linked immunosorbent assay reactivities to recombinant rhoptry-associated protein-1 (rRAP-1) as well as IgG reactivities to a repeat region of the acidic-basic repeat antigen (ABRA) increased with age. The proportion of responders with IgM reactivities to rRAP-1 increased with age in the first three decades. However, levels of IgG reactivities to rRAP-1 did not increase with age, indicating high levels of reactivities among young children. High P. falciparum densities were only detectable in children less than five years of age; in this group the proportion of IgG responders to rRAP-1 and to the ABRA repeat region was low but levels of IgG reactivities to rRAP-1 were inversely correlated with parasite density, suggesting that immune recognition of the antigen may be associated with resistance to infection. On the other hand, levels of IgG reactivities to the repeat region of ABRA increased with parasite densities in children 1-4 years of age. Two different profiles of IgG reactivities to rRAP-1 and to ABRA are detectable in young Tanzanian children and the Ig reactivities against rRAP-1 may be a component of the immune reactions restricting parasite multiplication.",

author = "Jakobsen, {P H} and Lemnge, {M M} and Abu-Zeid, {Y A} and Msangeni, {H A} and Salum, {F M} and Mhina, {J I} and Akida, {J A} and Ruta, {A S} and Ronn, {A M} and Heegaard, {P M} and Ridley, {R G} and Bygbjerg, {I C}",

note = "Keywords: Age Factors; Analysis of Variance; Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G; Immunoglobulin M; Infant; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; Prevalence; Protozoan Proteins; Recombinant Proteins; Tanzania",

year = "1996",

language = "English",

volume = "55",

pages = "642--6",

journal = "Journal. National Malaria Society",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

number = "6",

}

TY - JOUR

T1 - Immunoglobulin G reactivities to rhoptry-associated protein-1 associated with decreased levels of Plasmodium falciparum parasitemia in Tanzanian children

AU - Jakobsen, P H

AU - Lemnge, M M

AU - Abu-Zeid, Y A

AU - Msangeni, H A

AU - Salum, F M

AU - Mhina, J I

AU - Akida, J A

AU - Ruta, A S

AU - Ronn, A M

AU - Heegaard, P M

AU - Ridley, R G

AU - Bygbjerg, I C

N1 - Keywords: Age Factors; Analysis of Variance; Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G; Immunoglobulin M; Infant; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; Prevalence; Protozoan Proteins; Recombinant Proteins; Tanzania

PY - 1996

Y1 - 1996

N2 - In the Muheza region of Tanzania, an area with holoendemic malaria, the proportion of responders with IgG enzyme-linked immunosorbent assay reactivities to recombinant rhoptry-associated protein-1 (rRAP-1) as well as IgG reactivities to a repeat region of the acidic-basic repeat antigen (ABRA) increased with age. The proportion of responders with IgM reactivities to rRAP-1 increased with age in the first three decades. However, levels of IgG reactivities to rRAP-1 did not increase with age, indicating high levels of reactivities among young children. High P. falciparum densities were only detectable in children less than five years of age; in this group the proportion of IgG responders to rRAP-1 and to the ABRA repeat region was low but levels of IgG reactivities to rRAP-1 were inversely correlated with parasite density, suggesting that immune recognition of the antigen may be associated with resistance to infection. On the other hand, levels of IgG reactivities to the repeat region of ABRA increased with parasite densities in children 1-4 years of age. Two different profiles of IgG reactivities to rRAP-1 and to ABRA are detectable in young Tanzanian children and the Ig reactivities against rRAP-1 may be a component of the immune reactions restricting parasite multiplication.

AB - In the Muheza region of Tanzania, an area with holoendemic malaria, the proportion of responders with IgG enzyme-linked immunosorbent assay reactivities to recombinant rhoptry-associated protein-1 (rRAP-1) as well as IgG reactivities to a repeat region of the acidic-basic repeat antigen (ABRA) increased with age. The proportion of responders with IgM reactivities to rRAP-1 increased with age in the first three decades. However, levels of IgG reactivities to rRAP-1 did not increase with age, indicating high levels of reactivities among young children. High P. falciparum densities were only detectable in children less than five years of age; in this group the proportion of IgG responders to rRAP-1 and to the ABRA repeat region was low but levels of IgG reactivities to rRAP-1 were inversely correlated with parasite density, suggesting that immune recognition of the antigen may be associated with resistance to infection. On the other hand, levels of IgG reactivities to the repeat region of ABRA increased with parasite densities in children 1-4 years of age. Two different profiles of IgG reactivities to rRAP-1 and to ABRA are detectable in young Tanzanian children and the Ig reactivities against rRAP-1 may be a component of the immune reactions restricting parasite multiplication.

M3 - Journal article

C2 - 9025691

VL - 55

SP - 642

EP - 646

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

SN - 0002-9637

IS - 6

ER -