@article{98911c20ebce11ddbf70000ea68e967b,
title = "Immunological self, nonself discrimination",
abstract = "The ability of immunodominant peptides derived from several antigen systems to compete with each other for T cell activation was studied. Only peptides restricted by a given transplantation antigen are mutually competitive. There is a correlation between haplotype restriction, ability to bind to the appropriate transplantation antigen, and ability to inhibit activation of other T cells restricted by the same transplantation antigen. An exception was noted in that a peptide derived from an antigen, bacteriophage lambda cI repressor, binds to the I-Ed molecule in a specific way, yet is not I-Ed-restricted. Comparison of the sequence of the repressor peptide with that of other peptides able to bind to (and be restricted by) I-Ed and a polymorphic region of the I-Ed molecule itself revealed a significant degree of homology. Thus, peptides restricted by a given class II molecule appear to be homologous to a portion of the class II molecule itself. The repressor-derived peptide is identical at several polymorphic residues at this site, and this may account for the failure of I-Ed to act as a restriction element. Comparison of antigenic peptide sequences with transplantation antigen sequences suggests a model that provides a basis for explaining self, nonself discrimination as well as alloreactivity.",
author = "Guillet, {J G} and Lai, {M Z} and Briner, {T J} and S Buus and A Sette and Grey, {H M} and Smith, {J A} and Gefter, {M L}",
note = "Keywords: Animals; Antigens; Autoantigens; DNA-Binding Proteins; Epitopes; Histocompatibility Antigens Class II; Hybridomas; Isoantigens; Lymphocyte Activation; Mice; Micrococcal Nuclease; Ovalbumin; Protein Binding; Receptors, Immunologic; Repressor Proteins; T-Lymphocytes; T-Lymphocytes, Helper-Inducer; Viral Proteins; Viral Regulatory and Accessory Proteins",
year = "1987",
language = "English",
volume = "235",
pages = "865--70",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4791",
}