Impact of body composition changes on risk of all-cause mortality in older adults

Christophe E Graf; François R Herrmann; Adrian Spoerri; Anne-Marie Makhlouf; Thorkild I A Sørensen; Sylvain Ho; Véronique L Karsegard; Laurence Genton

doi:10.1016/j.clnu.2016.04.003

Impact of body composition changes on risk of all-cause mortality in older adults

Christophe E Graf, François R Herrmann, Adrian Spoerri, Anne-Marie Makhlouf, Thorkild I A Sørensen, Sylvain Ho, Véronique L Karsegard, Laurence Genton

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

21 Citationer (Scopus)

Abstract

PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years.

METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement.

RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70).

CONCLUSIONS: FFMI loss is related to increased mortality in older persons.

Originalsprog	Engelsk
Tidsskrift	Clinical Nutrition
Vol/bind	35
Udgave nummer	6
Sider (fra-til)	1499-1505
Antal sider	7
ISSN	0261-5614
DOI	https://doi.org/10.1016/j.clnu.2016.04.003
Status	Udgivet - dec. 2016

Adgang til dokumentet

10.1016/j.clnu.2016.04.003

Citationsformater

Impact of body composition changes on risk of all-cause mortality in older adults. / Graf, Christophe E; Herrmann, François R; Spoerri, Adrian; Makhlouf, Anne-Marie; Sørensen, Thorkild I A; Ho, Sylvain; Karsegard, Véronique L; Genton, Laurence.

I: Clinical Nutrition, Bind 35, Nr. 6, 12.2016, s. 1499-1505.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years.METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as {"}gain{"}, negative slopes as {"}loss{"} and the others as {"}maintenance{"}. The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement.RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70).CONCLUSIONS: FFMI loss is related to increased mortality in older persons.",

author = "Graf, {Christophe E} and Herrmann, {Fran{\c c}ois R} and Adrian Spoerri and Anne-Marie Makhlouf and S{\o}rensen, {Thorkild I A} and Sylvain Ho and Karsegard, {V{\'e}ronique L} and Laurence Genton",

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doi = "10.1016/j.clnu.2016.04.003",

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T1 - Impact of body composition changes on risk of all-cause mortality in older adults

AU - Graf, Christophe E

AU - Herrmann, François R

AU - Spoerri, Adrian

AU - Makhlouf, Anne-Marie

AU - Sørensen, Thorkild I A

AU - Ho, Sylvain

AU - Karsegard, Véronique L

AU - Genton, Laurence

PY - 2016/12

Y1 - 2016/12

N2 - PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years.METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement.RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70).CONCLUSIONS: FFMI loss is related to increased mortality in older persons.

AB - PURPOSE: This study evaluates the relationship between body mass index (BMI), fat mass index (FMI) and fat-free mass index (FFMI) changes and mortality in persons ≥65 years.METHODS: Adults ≥65 years with at least two body composition measurements (BCM) between 1990 and 2011 were included. We excluded persons who died within one month of the second BCM and who had two single BCM in a one-month timeframe. Mortality data was retrieved until December 2012. For each person, we calculated the regression slopes for BMI, FMI and FFMI changes. Significant positive slopes were categorized as "gain", negative slopes as "loss" and the others as "maintenance". The impact of body composition changes was evaluated by Cox regression models while adjusting for sex, age, co-morbidities and body composition at the last measurement.RESULTS: We included 791 persons with 3049 BCM. After adjustment for sex, and age and co-morbidities, a loss of FFMI, but not of FMI or BMI, increased the risk of mortality (HR 2.02, 95%CI 1.28-3.19). The prediction of mortality with FFMI loss remained significant when further adjusting for FMI loss and the last available body composition (HR 1.68, 95%CI 1.04-2.70).CONCLUSIONS: FFMI loss is related to increased mortality in older persons.

U2 - 10.1016/j.clnu.2016.04.003

DO - 10.1016/j.clnu.2016.04.003

M3 - Journal article

C2 - 27126709

VL - 35

SP - 1499

EP - 1505

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

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