Impact of dietary exposure to food contaminants on the risk of Parkinson's disease

Maria Skaalum Petersen; Jónrit Halling; Sára Bech; Lene Wermuth; Pál Weihe; Flemming Nielsen; Poul J Jørgensen; Esben Budtz-Jørgensen; Philippe Grandjean

doi:10.1016/j.neuro.2008.03.001

Impact of dietary exposure to food contaminants on the risk of Parkinson's disease

Maria Skaalum Petersen, Jónrit Halling, Sára Bech, Lene Wermuth, Pál Weihe, Flemming Nielsen, Poul J Jørgensen, Esben Budtz-Jørgensen, Philippe Grandjean

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

72 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-Jul

Originalsprog	Engelsk
Tidsskrift	NeuroToxicology
Vol/bind	29
Udgave nummer	4
Sider (fra-til)	584-90
Antal sider	6
ISSN	0161-813X
DOI	https://doi.org/10.1016/j.neuro.2008.03.001
Status	Udgivet - 2008

Bibliografisk note

Keywords: Aged; Aged, 80 and over; Case-Control Studies; Confidence Intervals; Diet; Environmental Exposure; Female; Food Contamination; Humans; Male; Neurologic Examination; Occupational Diseases; Odds Ratio; Parkinson Disease; Risk; Sex Factors

Adgang til dokumentet

10.1016/j.neuro.2008.03.001

Citationsformater

Impact of dietary exposure to food contaminants on the risk of Parkinson's disease. / Petersen, Maria Skaalum; Halling, Jónrit; Bech, Sára; Wermuth, Lene; Weihe, Pál; Nielsen, Flemming; Jørgensen, Poul J; Budtz-Jørgensen, Esben; Grandjean, Philippe.

I: NeuroToxicology, Bind 29, Nr. 4, 2008, s. 584-90.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Impact of dietary exposure to food contaminants on the risk of Parkinson's disease",

abstract = "This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.",

author = "Petersen, {Maria Skaalum} and J{\'o}nrit Halling and S{\'a}ra Bech and Lene Wermuth and P{\'a}l Weihe and Flemming Nielsen and J{\o}rgensen, {Poul J} and Esben Budtz-J{\o}rgensen and Philippe Grandjean",

note = "Keywords: Aged; Aged, 80 and over; Case-Control Studies; Confidence Intervals; Diet; Environmental Exposure; Female; Food Contamination; Humans; Male; Neurologic Examination; Occupational Diseases; Odds Ratio; Parkinson Disease; Risk; Sex Factors",

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T1 - Impact of dietary exposure to food contaminants on the risk of Parkinson's disease

AU - Petersen, Maria Skaalum

AU - Halling, Jónrit

AU - Bech, Sára

AU - Wermuth, Lene

AU - Weihe, Pál

AU - Nielsen, Flemming

AU - Jørgensen, Poul J

AU - Budtz-Jørgensen, Esben

AU - Grandjean, Philippe

N1 - Keywords: Aged; Aged, 80 and over; Case-Control Studies; Confidence Intervals; Diet; Environmental Exposure; Female; Food Contamination; Humans; Male; Neurologic Examination; Occupational Diseases; Odds Ratio; Parkinson Disease; Risk; Sex Factors

PY - 2008

Y1 - 2008

N2 - This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.

AB - This study aimed to investigate the association of Parkinson's disease (PD) with dietary exposure to polychlorinated biphenyls (PCBs) and methylmercury (MeHg) in a community with increased exposure levels. A total of 79 clinically verified idiopathic PD cases and 154 controls matched by sex and age were examined in this case-control study in the Faroe Islands. Blood and hair samples were collected and a questionnaire recorded lifetime information on residence, dietary habits, smoking history, and occupational exposure to solvents, pesticides, and metals. Both unconditional and conditional logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) in regard to relevant exposure variables. Increased ORs for dietary intakes of whale meat and blubber during adult life were statistically significant. The ORs for occupational exposure to solvents, pesticides and metals also suggested an increased risk for PD. Current serum concentrations of summation operator PCB and related contaminants suggested slightly increased ORs, although only beta-hexachlorocyclohexane (beta-HCH) was statistically significant. Increased intake of whale meat and blubber in adult life was significantly associated with PD, thus suggesting a positive association between previous exposure to marine food contaminants and development of PD.

U2 - 10.1016/j.neuro.2008.03.001

DO - 10.1016/j.neuro.2008.03.001

M3 - Journal article

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JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

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