Impact of obesity as a mortality predictor in high-risk patients with myocardial infarction or chronic heart failure: a pooled analysis of five registries

Jawdat Abdulla; Lars Køber; Steen Z Abildstrøm; Erik Christensen; W Philip T James; Christian Torp-Pedersen

doi:10.1093/eurheartj/ehn010

Impact of obesity as a mortality predictor in high-risk patients with myocardial infarction or chronic heart failure: a pooled analysis of five registries

Jawdat Abdulla, Lars Køber, Steen Z Abildstrøm, Erik Christensen, W Philip T James, Christian Torp-Pedersen

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

53 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-Mar

Originalsprog	Engelsk
Tidsskrift	European Heart Journal
Vol/bind	29
Udgave nummer	5
Sider (fra-til)	594-601
Antal sider	7
ISSN	0195-668X
DOI	https://doi.org/10.1093/eurheartj/ehn010
Status	Udgivet - 2008

Bibliografisk note

Keywords: Aged; Aged, 80 and over; Body Mass Index; Chronic Disease; Epidemiologic Methods; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Obesity

Adgang til dokumentet

10.1093/eurheartj/ehn010

Citationsformater

@article{bf62fe70118611df803f000ea68e967b,

title = "Impact of obesity as a mortality predictor in high-risk patients with myocardial infarction or chronic heart failure: a pooled analysis of five registries",

abstract = "AIMS: To explore the influence of obesity on prognosis in high-risk patients with myocardial infarction (MI) or heart failure (HF). METHODS AND RESULTS: Individual data of 21 570 consecutively hospitalized patients from five Danish registries were pooled together. After a follow-up of 10.4 years, all-cause mortality using multivariate model and adjusted hazard ratios (HR) with 95% confidence intervals were calculated. Compared with normal weight [body mass index (BMI) 18.5-24.9 kg/m2], obesity class II (BMI >or= 35 kg/m2) was associated with increased risk of death in patients with MI but not HF [HR = 1.23 (1.06-1.44), P = 0.006 and HR = 1.13 (0.95-1.36), P = 0.95] (P-value for interaction = 0.004). Obesity class I (BMI 30-34.9 kg/m2) was not associated with increased risk of death in MI or HF [HR = 0.99 (0.92-1.08) and 1.00 (0.90-1.11), P > 0.1]. Pre-obesity (BMI 25-29.9 kg/m2) was associated with decreased death risk in MI but not HF [HR = 0.91 (0.87-0.96), P = 0.0006 and 1.04 (0.97-1.12), P = 0.34] (P-value for interaction = 0.007). Underweight (BMI < 18.5 kg/m2) patients were in increased death risk regardless of MI or HF [HR = 1.54 (1.35-1.75) and 1.37 (1.18-1.59), P < 0.001]. CONCLUSION: In patients with MI but not HF, the relationship between BMI and mortality is U-shaped with highest mortality in underweight and obese class II, but lowest in the other BMI classes.",

author = "Jawdat Abdulla and Lars K{\o}ber and Abildstr{\o}m, {Steen Z} and Erik Christensen and James, {W Philip T} and Christian Torp-Pedersen",

note = "Keywords: Aged; Aged, 80 and over; Body Mass Index; Chronic Disease; Epidemiologic Methods; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Obesity",

year = "2008",

doi = "10.1093/eurheartj/ehn010",

language = "English",

volume = "29",

pages = "594--601",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "5",

}

TY - JOUR

T1 - Impact of obesity as a mortality predictor in high-risk patients with myocardial infarction or chronic heart failure: a pooled analysis of five registries

AU - Abdulla, Jawdat

AU - Køber, Lars

AU - Abildstrøm, Steen Z

AU - Christensen, Erik

AU - James, W Philip T

AU - Torp-Pedersen, Christian

N1 - Keywords: Aged; Aged, 80 and over; Body Mass Index; Chronic Disease; Epidemiologic Methods; Female; Heart Failure; Humans; Male; Middle Aged; Myocardial Infarction; Obesity

PY - 2008

Y1 - 2008

N2 - AIMS: To explore the influence of obesity on prognosis in high-risk patients with myocardial infarction (MI) or heart failure (HF). METHODS AND RESULTS: Individual data of 21 570 consecutively hospitalized patients from five Danish registries were pooled together. After a follow-up of 10.4 years, all-cause mortality using multivariate model and adjusted hazard ratios (HR) with 95% confidence intervals were calculated. Compared with normal weight [body mass index (BMI) 18.5-24.9 kg/m2], obesity class II (BMI >or= 35 kg/m2) was associated with increased risk of death in patients with MI but not HF [HR = 1.23 (1.06-1.44), P = 0.006 and HR = 1.13 (0.95-1.36), P = 0.95] (P-value for interaction = 0.004). Obesity class I (BMI 30-34.9 kg/m2) was not associated with increased risk of death in MI or HF [HR = 0.99 (0.92-1.08) and 1.00 (0.90-1.11), P > 0.1]. Pre-obesity (BMI 25-29.9 kg/m2) was associated with decreased death risk in MI but not HF [HR = 0.91 (0.87-0.96), P = 0.0006 and 1.04 (0.97-1.12), P = 0.34] (P-value for interaction = 0.007). Underweight (BMI < 18.5 kg/m2) patients were in increased death risk regardless of MI or HF [HR = 1.54 (1.35-1.75) and 1.37 (1.18-1.59), P < 0.001]. CONCLUSION: In patients with MI but not HF, the relationship between BMI and mortality is U-shaped with highest mortality in underweight and obese class II, but lowest in the other BMI classes.

AB - AIMS: To explore the influence of obesity on prognosis in high-risk patients with myocardial infarction (MI) or heart failure (HF). METHODS AND RESULTS: Individual data of 21 570 consecutively hospitalized patients from five Danish registries were pooled together. After a follow-up of 10.4 years, all-cause mortality using multivariate model and adjusted hazard ratios (HR) with 95% confidence intervals were calculated. Compared with normal weight [body mass index (BMI) 18.5-24.9 kg/m2], obesity class II (BMI >or= 35 kg/m2) was associated with increased risk of death in patients with MI but not HF [HR = 1.23 (1.06-1.44), P = 0.006 and HR = 1.13 (0.95-1.36), P = 0.95] (P-value for interaction = 0.004). Obesity class I (BMI 30-34.9 kg/m2) was not associated with increased risk of death in MI or HF [HR = 0.99 (0.92-1.08) and 1.00 (0.90-1.11), P > 0.1]. Pre-obesity (BMI 25-29.9 kg/m2) was associated with decreased death risk in MI but not HF [HR = 0.91 (0.87-0.96), P = 0.0006 and 1.04 (0.97-1.12), P = 0.34] (P-value for interaction = 0.007). Underweight (BMI < 18.5 kg/m2) patients were in increased death risk regardless of MI or HF [HR = 1.54 (1.35-1.75) and 1.37 (1.18-1.59), P < 0.001]. CONCLUSION: In patients with MI but not HF, the relationship between BMI and mortality is U-shaped with highest mortality in underweight and obese class II, but lowest in the other BMI classes.

U2 - 10.1093/eurheartj/ehn010

DO - 10.1093/eurheartj/ehn010

M3 - Journal article

C2 - 18270214

SN - 0195-668X

VL - 29

SP - 594

EP - 601

JO - European Heart Journal

JF - European Heart Journal

IS - 5

ER -