Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis

Asa Andersson; Magnus Isaksson; Judit Wefer; Anna Norling; Amilcar Flores Morales; Fredrik Rorsman; Olle Kämpe; Robert A Harris; Anna Lobell

doi:10.1371/journal.pone.0003682

Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis

Asa Andersson, Magnus Isaksson, Judit Wefer, Anna Norling, Amilcar Flores Morales, Fredrik Rorsman, Olle Kämpe, Robert A Harris, Anna Lobell

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

18 Citationer (Scopus)

Abstract

We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated with early induction of Interferon (IFN)-beta.

Originalsprog	Engelsk
Tidsskrift	PLOS ONE
Vol/bind	3
Udgave nummer	11
Sider (fra-til)	e3682
DOI	https://doi.org/10.1371/journal.pone.0003682
Status	Udgivet - 2008
Udgivet eksternt	Ja

Adgang til dokumentet

10.1371/journal.pone.0003682

Citationsformater

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title = "Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis",

abstract = "We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated with early induction of Interferon (IFN)-beta.",

author = "Asa Andersson and Magnus Isaksson and Judit Wefer and Anna Norling and {Flores Morales}, Amilcar and Fredrik Rorsman and Olle K{\"a}mpe and Harris, {Robert A} and Anna Lobell",

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T1 - Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis

AU - Andersson, Asa

AU - Isaksson, Magnus

AU - Wefer, Judit

AU - Norling, Anna

AU - Flores Morales, Amilcar

AU - Rorsman, Fredrik

AU - Kämpe, Olle

AU - Harris, Robert A

AU - Lobell, Anna

PY - 2008

Y1 - 2008

N2 - We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated with early induction of Interferon (IFN)-beta.

AB - We have previously shown that vaccination with DNA encoding the encephalitogenic peptide myelin oligodendrocyte glycoprotein (MOG)(91-108) (pMOG) suppresses MOG(91-108)-induced rat Experimental Autoimmune Encephalomyelitis (EAE), a model for human Multiple Sclerosis (MS). The suppressive effect of pMOG is dependent on inclusion of CpG DNA in the plasmid backbone and is associated with early induction of Interferon (IFN)-beta.

U2 - 10.1371/journal.pone.0003682

DO - 10.1371/journal.pone.0003682

M3 - Journal article

C2 - 18997868

SN - 1553-7358

SN - 1932-6203

VL - 3

SP - e3682

JO - PLOS ONE

JF - PLOS ONE

IS - 11

ER -