Improved insulin sensitivity after exercise: focus on insulin signaling

Christian Frøsig, Erik A. Richter

    Publikation: Bidrag til tidsskriftReviewForskning

    97 Citationer (Scopus)

    Abstract

    After a single bout of exercise, the ability of insulin to stimulate glucose uptake is markedly improved locally in the previously active muscles. This makes exercise a potent stimulus counteracting insulin resistance characterizing type 2 diabetes (T2D). It is believed that at least part of the mechanism relates to an improved ability of insulin to stimulate translocation of glucose transporters (GLUT4) to the muscle membrane after exercise. How this is accomplished is still unclear; however, an obvious possibility is that exercise interacts with the insulin signaling pathway to GLUT4 translocation allowing for a more potent insulin response. Parallel to unraveling of the insulin signaling cascade, this has been investigated within the past 25 years. Reviewing existing studies clearly indicates that improved insulin action can occur independent of interactions with proximal insulin signaling. In contrast, more recent observations indicate that interactions exist at the distal signaling level of AS160 and atypical protein kinase C (aPKC). Although the functional interpretation is lacking, these novel observations may present a breakthrough in understanding the beneficial interplay between exercise and insulin action.
    OriginalsprogEngelsk
    TidsskriftObesity
    Vol/bind17
    Udgave nummerSuppl. 3
    Sider (fra-til)S15-S20
    Antal sider6
    ISSN1930-7381
    DOI
    StatusUdgivet - 2009

    Bibliografisk note

    CURIS 2009 5200 176

    Citationsformater