Improved Positron Emission Tomography Quantification: Evaluation of a Maximum-Likelihood Scatter Scaling Algorithm

Nanna Overbeck, Sahar Ahangari, Maurizio Conti, Vladimir Panin, Aleena Azam, Sorel Kurbegovic, Andreas Kjær, Liselotte Højgaard, Kirsten Korsholm, Barbara Malene Fischer, Flemming Littrup Andersen, Thomas Lund Andersen*

*Corresponding author af dette arbejde

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Abstract

Incorrect scatter scaling of positron emission tomography (PET) images can lead to halo artifacts, quantitative bias, or reconstruction failure. Tail-fitted scatter scaling (TFSS) possesses performance limitations in multiple cases. This study aims to investigate a novel method for scatter scaling: maximum-likelihood scatter scaling (MLSS) in scenarios where TFSS tends to induce artifacts or are observed to cause reconstruction abortion. [68Ga]Ga-RGD PET scans of nine patients were included in cohort 1 in the scope of investigating the reduction of halo artifacts relative to the scatter estimation method. PET scans of 30 patients administrated with [68Ga]Ga-uPAR were included in cohort 2, used for an evaluation of the robustness of MLSS in cases where TFSS-integrated reconstructions are observed to fail. A visual inspection of MLSS-corrected images scored higher than TFSS-corrected reconstructions of cohort 1. The quantitative investigation near the bladder showed a relative difference in tracer uptake of up to 94.7%. A reconstruction of scans included in cohort 2 resulted in failure in 23 cases when TFSS was used. The lesion uptake values of cohort 2 showed no significant difference. MLSS is suggested as an alternative scatter-scaling method relative to TFSS with the aim of reducing halo artifacts and a robust reconstruction process.

OriginalsprogEngelsk
Artikelnummer1075
TidsskriftDiagnostics
Vol/bind14
Udgave nummer11
Antal sider11
ISSN2075-4418
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
This project has received funding from the European Union\u2019s Horizon 2020 research and innovation program under the Marie Sk\u0142odowska-Curie Grant Agreement No. 764458.

Publisher Copyright:
© 2024 by the authors.

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