Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes

Umme Kolsum; Zoë Borrill; Kay Roy; Cerys Starkey; Jørgen Vestbo; Catherine Houghton; Dave Singh

doi:10.1016/j.rmed.2008.07.014

Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes

Umme Kolsum, Zoë Borrill, Kay Roy, Cerys Starkey, Jørgen Vestbo, Catherine Houghton, Dave Singh

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

101 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Jan

Originalsprog	Engelsk
Tidsskrift	Respiratory Medicine
Vol/bind	103
Udgave nummer	1
Sider (fra-til)	136-43
Antal sider	7
ISSN	0954-6111
DOI	https://doi.org/10.1016/j.rmed.2008.07.014
Status	Udgivet - 2008

Bibliografisk note

Keywords: Aged; Airway Obstruction; Airway Resistance; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Oscillometry; Plethysmography, Whole Body; Pulmonary Disease, Chronic Obstructive; Sensitivity and Specificity; Spirometry; Statistics, Nonparametric; Tidal Volume; Total Lung Capacity

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10.1016/j.rmed.2008.07.014

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Citationsformater

@article{b639ddb0b4ff11df825b000ea68e967b,

title = "Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes",

abstract = "BACKGROUND: Impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. We set out to investigate which IOS measurements are related to airflow obstruction, airway conductance and lung volumes in chronic obstructive pulmonary disease (COPD). METHODS: Ninety-four COPD patients were recruited and 58 agreed to follow up after 1 year. IOS measurements (R5, R20, X5 & Fres), body plethysmography (sGaw, FRC, TLC, RV & IC) and spirometry (FEV(1)) were performed. Pearson or Spearman correlation determined the relationships between IOS and other measurements. RESULTS: R5, X5 and Fres were all significantly associated (p<0.05) with FEV(1), sGaw, TLC, RV and IC. However, R20 was not related to any of these measurements except for RV. The strongest associations were observed between FEV(1) and the reactance measurements X5 (r=0.48) and Fres (r=-0.44), and sGaw with X5 (r=0.47) and Fres (r=0.51). The r values for the associations with TLC and IC were all <0.25. There was no statistically significant change in the FEV(1), R5, X5 or Fres after 1 year, but R20 significantly increased over the year. The changes in R5 and R20 did not significantly correlate with the changes in FEV(1). In contrast, X5 changes were significantly related to FEV(1) changes over 1 year (r=-0.27, p=0.05), while for Fres changes there was a trend to statistical significance (p=0.08). CONCLUSIONS: IOS reactance measurements are more closely related than resistance measurements to other pulmonary function measurements in COPD patients. The IOS reactance measurements appear to be indicative of changes in pulmonary compliance caused by airflow obstruction.",

author = "Umme Kolsum and Zo{\"e} Borrill and Kay Roy and Cerys Starkey and J{\o}rgen Vestbo and Catherine Houghton and Dave Singh",

note = "Keywords: Aged; Airway Obstruction; Airway Resistance; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Oscillometry; Plethysmography, Whole Body; Pulmonary Disease, Chronic Obstructive; Sensitivity and Specificity; Spirometry; Statistics, Nonparametric; Tidal Volume; Total Lung Capacity",

year = "2008",

doi = "10.1016/j.rmed.2008.07.014",

language = "English",

volume = "103",

pages = "136--43",

journal = "Respiratory Medicine",

issn = "0954-6111",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes

AU - Kolsum, Umme

AU - Borrill, Zoë

AU - Roy, Kay

AU - Starkey, Cerys

AU - Vestbo, Jørgen

AU - Houghton, Catherine

AU - Singh, Dave

N1 - Keywords: Aged; Airway Obstruction; Airway Resistance; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Lung; Male; Middle Aged; Oscillometry; Plethysmography, Whole Body; Pulmonary Disease, Chronic Obstructive; Sensitivity and Specificity; Spirometry; Statistics, Nonparametric; Tidal Volume; Total Lung Capacity

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. We set out to investigate which IOS measurements are related to airflow obstruction, airway conductance and lung volumes in chronic obstructive pulmonary disease (COPD). METHODS: Ninety-four COPD patients were recruited and 58 agreed to follow up after 1 year. IOS measurements (R5, R20, X5 & Fres), body plethysmography (sGaw, FRC, TLC, RV & IC) and spirometry (FEV(1)) were performed. Pearson or Spearman correlation determined the relationships between IOS and other measurements. RESULTS: R5, X5 and Fres were all significantly associated (p<0.05) with FEV(1), sGaw, TLC, RV and IC. However, R20 was not related to any of these measurements except for RV. The strongest associations were observed between FEV(1) and the reactance measurements X5 (r=0.48) and Fres (r=-0.44), and sGaw with X5 (r=0.47) and Fres (r=0.51). The r values for the associations with TLC and IC were all <0.25. There was no statistically significant change in the FEV(1), R5, X5 or Fres after 1 year, but R20 significantly increased over the year. The changes in R5 and R20 did not significantly correlate with the changes in FEV(1). In contrast, X5 changes were significantly related to FEV(1) changes over 1 year (r=-0.27, p=0.05), while for Fres changes there was a trend to statistical significance (p=0.08). CONCLUSIONS: IOS reactance measurements are more closely related than resistance measurements to other pulmonary function measurements in COPD patients. The IOS reactance measurements appear to be indicative of changes in pulmonary compliance caused by airflow obstruction.

AB - BACKGROUND: Impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. We set out to investigate which IOS measurements are related to airflow obstruction, airway conductance and lung volumes in chronic obstructive pulmonary disease (COPD). METHODS: Ninety-four COPD patients were recruited and 58 agreed to follow up after 1 year. IOS measurements (R5, R20, X5 & Fres), body plethysmography (sGaw, FRC, TLC, RV & IC) and spirometry (FEV(1)) were performed. Pearson or Spearman correlation determined the relationships between IOS and other measurements. RESULTS: R5, X5 and Fres were all significantly associated (p<0.05) with FEV(1), sGaw, TLC, RV and IC. However, R20 was not related to any of these measurements except for RV. The strongest associations were observed between FEV(1) and the reactance measurements X5 (r=0.48) and Fres (r=-0.44), and sGaw with X5 (r=0.47) and Fres (r=0.51). The r values for the associations with TLC and IC were all <0.25. There was no statistically significant change in the FEV(1), R5, X5 or Fres after 1 year, but R20 significantly increased over the year. The changes in R5 and R20 did not significantly correlate with the changes in FEV(1). In contrast, X5 changes were significantly related to FEV(1) changes over 1 year (r=-0.27, p=0.05), while for Fres changes there was a trend to statistical significance (p=0.08). CONCLUSIONS: IOS reactance measurements are more closely related than resistance measurements to other pulmonary function measurements in COPD patients. The IOS reactance measurements appear to be indicative of changes in pulmonary compliance caused by airflow obstruction.

U2 - 10.1016/j.rmed.2008.07.014

DO - 10.1016/j.rmed.2008.07.014

M3 - Journal article

C2 - 18760576

SN - 0954-6111

VL - 103

SP - 136

EP - 143

JO - Respiratory Medicine

JF - Respiratory Medicine

IS - 1

ER -