Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | British Journal of Cancer |
| Vol/bind | 103 |
| Udgave nummer | 3 |
| Sider (fra-til) | 310-4 |
| Antal sider | 4 |
| ISSN | 0007-0920 |
| DOI | |
| Status | Udgivet - 2010 |
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Incomplete follow-up of positive HPV tests: overview of randomised controlled trials on primary cervical screening. / Rebolj, M; Lynge, E.
I: British Journal of Cancer, Bind 103, Nr. 3, 2010, s. 310-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Incomplete follow-up of positive HPV tests: overview of randomised controlled trials on primary cervical screening
AU - Rebolj, M
AU - Lynge, E
PY - 2010
Y1 - 2010
N2 - Background:It has been suggested that adjustment for incomplete compliance with follow-up in women with positive human papillomavirus (HPV) tests would be appropriate for estimating the true sensitivity of cervical screening with HPV testing. We assessed the compliance and its impact on >/=CIN3 detection in all eight randomised controlled trials (RCT) with published baseline-round data.Methods:We extracted data on recommended follow-up procedures, follow-up compliance, and >/=CIN3 detection for both arms of each RCT, and assessed their correlation.Results:Compliance with a direct referral for colposcopy was around 90% in all RCTs, whereas compliance with repeated testing among HPV-positive/cytology-negative women was around 60% in three RCTs and 73% in one RCT. Detection of >/=CIN3 was significantly increased in two out of six RCTs with reported data. The correlation between compliance with follow-up in HPV-positive women and relative >/=CIN3 detection was 0.48 (P=0.33).Conclusion:There is at present scant evidence to support the view that the measured sensitivity of HPV screening is a simple reflection of compliance with follow-up. Adjustment of measured cervical intraepithelial neoplasia detection on the basis of compliance data may not always be justifiable, and if adjustment is made, it should be used very judiciously.
AB - Background:It has been suggested that adjustment for incomplete compliance with follow-up in women with positive human papillomavirus (HPV) tests would be appropriate for estimating the true sensitivity of cervical screening with HPV testing. We assessed the compliance and its impact on >/=CIN3 detection in all eight randomised controlled trials (RCT) with published baseline-round data.Methods:We extracted data on recommended follow-up procedures, follow-up compliance, and >/=CIN3 detection for both arms of each RCT, and assessed their correlation.Results:Compliance with a direct referral for colposcopy was around 90% in all RCTs, whereas compliance with repeated testing among HPV-positive/cytology-negative women was around 60% in three RCTs and 73% in one RCT. Detection of >/=CIN3 was significantly increased in two out of six RCTs with reported data. The correlation between compliance with follow-up in HPV-positive women and relative >/=CIN3 detection was 0.48 (P=0.33).Conclusion:There is at present scant evidence to support the view that the measured sensitivity of HPV screening is a simple reflection of compliance with follow-up. Adjustment of measured cervical intraepithelial neoplasia detection on the basis of compliance data may not always be justifiable, and if adjustment is made, it should be used very judiciously.
U2 - 10.1038/sj.bjc.6605771
DO - 10.1038/sj.bjc.6605771
M3 - Journal article
C2 - 20628384
VL - 103
SP - 310
EP - 314
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
IS - 3
ER -