@article{b87b2e40fda311ddb219000ea68e967b,
title = "Increased frequency of HLA-DPw2 in pauciarticular onset juvenile chronic arthritis",
abstract = "Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.",
author = "Niels {\O}dum and Niels Morling and J Friis and C Heilmann and Hyldig-Nielsen, {J J} and Jakobsen, {B K} and Pedersen, {F K} and P Platz and Ryder, {L P} and A Svejgaard",
note = "Keywords: Arthritis, Juvenile Rheumatoid; Child; Child, Preschool; Denmark; Female; HLA-D Antigens; HLA-DP Antigens; HLA-DR Antigens; HLA-DR5 Antigen; Histocompatibility Antigens Class II; Humans; Infant; Male",
year = "1986",
language = "English",
volume = "28",
pages = "245--50",
journal = "HLA",
issn = "2059-2302",
publisher = "Wiley",
number = "4",
}