Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin

Anna Tsakiri, Dimitris Tsiantoulas, Jette Frederiksen, Inge Marie Svane

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    Abstract

    Multiple sclerosis (MS) is an autoimmune disease where myelin-reactive lymphocytes and their activation depend on interactions with antigen presenting cells (APCs). Dendritic cells (DC) are professional APCs dependent on maturation to attain full T-cell priming capacity. The immunomodulatory properties of simvastatin influence the function of both T cells and APCs and could thus be a potential therapy for MS. The phenotype of myeloid DC in untreated patients with monosymptomatic optic neuritis (ON) was determined by flow cytometry and the impact of simvastatin on the function of myeloid DC derived from peripheral blood mononuclear cells (PBMC) was analysed in vitro. DC from ON patients had more mature phenotype compared with healthy controls (HC). Particularly the fraction of DC expressing CD1a and CD80 was significantly higher in ON than in HC (P
    OriginalsprogEngelsk
    TidsskriftExperimental Neurology
    Vol/bind221
    Udgave nummer2
    Sider (fra-til)320-8
    Antal sider9
    ISSN0014-4886
    DOI
    StatusUdgivet - 1 feb. 2010

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