Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice

Helle K Knutsen; Hege B Olstørn; Jan Erik Paulsen; Trine Husøy; Ingeborg L Goverud; Else Marit Løberg; Karsten Kristiansen; Jan Alexander

Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice

Helle K Knutsen, Hege B Olstørn, Jan Erik Paulsen, Trine Husøy, Ingeborg L Goverud, Else Marit Løberg, Karsten Kristiansen, Jan Alexander

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

17 Citationer (Scopus)

Abstract

In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.

Originalsprog	Engelsk
Tidsskrift	Anticancer Research
Vol/bind	25
Udgave nummer	6B
Sider (fra-til)	3781-9
Antal sider	9
ISSN	0250-7005
Status	Udgivet - 2011
Udgivet eksternt	Ja

Citationsformater

@article{f4870080e7ab440ca828dfa49bd316fa,

title = "Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice",

abstract = "In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.",

author = "Knutsen, {Helle K} and Olst{\o}rn, {Hege B} and Paulsen, {Jan Erik} and Trine Hus{\o}y and Goverud, {Ingeborg L} and L{\o}berg, {Else Marit} and Karsten Kristiansen and Jan Alexander",

year = "2011",

language = "English",

volume = "25",

pages = "3781--9",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "6B",

}

TY - JOUR

T1 - Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice

AU - Knutsen, Helle K

AU - Olstørn, Hege B

AU - Paulsen, Jan Erik

AU - Husøy, Trine

AU - Goverud, Ingeborg L

AU - Løberg, Else Marit

AU - Kristiansen, Karsten

AU - Alexander, Jan

PY - 2011

Y1 - 2011

N2 - In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.

AB - In Apc(Min/+) (Min; multiple intestinal neoplasia) mice two separate populations of aberrant crypt foci (ACF) develop in the colon after azoxymethane (AOM) exposure. ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not.

M3 - Journal article

C2 - 16309164

SN - 0250-7005

VL - 25

SP - 3781

EP - 3789

JO - Anticancer Research

JF - Anticancer Research

IS - 6B

ER -