TY - JOUR
T1 - Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery
T2 - follow-up of a randomized clinical trial
AU - Meyhoff, Christian Sylvest
AU - Jorgensen, Lars N
AU - Wetterslev, Jørn
AU - Christensen, Karl Bang
AU - Rasmussen, Lars S
AU - PROXI Trial Group
PY - 2012
Y1 - 2012
N2 - A high perioperative inspiratory oxygen fraction (80%) has been recommended to prevent postoperative wound infections. However, the most recent and one of the largest trials, the PROXI trial, found no reduction in surgical site infection, and 30-day mortality was higher in patients given 80% oxygen. In this follow-up study of the PROXI trial we assessed the association between long-term mortality and perioperative oxygen fraction in patients undergoing abdominal surgery.
AB - A high perioperative inspiratory oxygen fraction (80%) has been recommended to prevent postoperative wound infections. However, the most recent and one of the largest trials, the PROXI trial, found no reduction in surgical site infection, and 30-day mortality was higher in patients given 80% oxygen. In this follow-up study of the PROXI trial we assessed the association between long-term mortality and perioperative oxygen fraction in patients undergoing abdominal surgery.
U2 - 10.1213/ANE.0b013e3182652a51
DO - 10.1213/ANE.0b013e3182652a51
M3 - Journal article
C2 - 22798533
SN - 0003-2999
VL - 115
SP - 849
EP - 854
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 4
ER -