Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving

Dean F Wong; Hiroto Kuwabara; David J Schretlen; Katherine R Bonson; Yun Zhou; Ayon Nandi; James R Brasic; Alane S Kimes; Marika A Maris; Anil Kumar; Carlo Contoreggi; Jonathan Links; Monique Ernst; Olivier Rousset; Stephen Zukin; Anthony A Grace; Jae Sung Lee; Charles Rohde; Donald R Jasinski; Albert Gjedde; Edythe D London

doi:10.1038/sj.npp.1301194

Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving

Dean F Wong, Hiroto Kuwabara, David J Schretlen, Katherine R Bonson, Yun Zhou, Ayon Nandi, James R Brasic, Alane S Kimes, Marika A Maris, Anil Kumar, Carlo Contoreggi, Jonathan Links, Monique Ernst, Olivier Rousset, Stephen Zukin, Anthony A Grace, Jae Sung Lee, Charles Rohde, Donald R Jasinski, Albert GjeddeEdythe D London

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

269 Citationer (Scopus)

Abstract

Udgivelsesdato: 2006-Dec

Originalsprog	Engelsk
Tidsskrift	Neuropsychopharmacology
Vol/bind	31
Udgave nummer	12
Sider (fra-til)	2716-27
Antal sider	11
ISSN	0893-133X
DOI	https://doi.org/10.1038/sj.npp.1301194
Status	Udgivet - 2006
Udgivet eksternt	Ja

Adgang til dokumentet

10.1038/sj.npp.1301194

Citationsformater

Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brasic, J. R., Kimes, A. S., Maris, M. A., Kumar, A., Contoreggi, C., Links, J., Ernst, M., Rousset, O., Zukin, S., Grace, A. A., Lee, J. S., Rohde, C., Jasinski, D. R., ... London, E. D. (2006). Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving. Neuropsychopharmacology, 31(12), 2716-27. https://doi.org/10.1038/sj.npp.1301194

Wong, DF, Kuwabara, H, Schretlen, DJ, Bonson, KR, Zhou, Y, Nandi, A, Brasic, JR, Kimes, AS, Maris, MA, Kumar, A, Contoreggi, C, Links, J, Ernst, M, Rousset, O, Zukin, S, Grace, AA, Lee, JS, Rohde, C, Jasinski, DR, Gjedde, A & London, ED 2006, 'Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving', Neuropsychopharmacology, bind 31, nr. 12, s. 2716-27. https://doi.org/10.1038/sj.npp.1301194

@article{2d558cc0b31511debc73000ea68e967b,

title = "Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving",

abstract = "In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.",

author = "Wong, {Dean F} and Hiroto Kuwabara and Schretlen, {David J} and Bonson, {Katherine R} and Yun Zhou and Ayon Nandi and Brasic, {James R} and Kimes, {Alane S} and Maris, {Marika A} and Anil Kumar and Carlo Contoreggi and Jonathan Links and Monique Ernst and Olivier Rousset and Stephen Zukin and Grace, {Anthony A} and Lee, {Jae Sung} and Charles Rohde and Jasinski, {Donald R} and Albert Gjedde and London, {Edythe D}",

year = "2006",

doi = "10.1038/sj.npp.1301194",

language = "English",

volume = "31",

pages = "2716--27",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "nature publishing group",

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TY - JOUR

T1 - Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving

AU - Wong, Dean F

AU - Kuwabara, Hiroto

AU - Schretlen, David J

AU - Bonson, Katherine R

AU - Zhou, Yun

AU - Nandi, Ayon

AU - Brasic, James R

AU - Kimes, Alane S

AU - Maris, Marika A

AU - Kumar, Anil

AU - Contoreggi, Carlo

AU - Links, Jonathan

AU - Ernst, Monique

AU - Rousset, Olivier

AU - Zukin, Stephen

AU - Grace, Anthony A

AU - Lee, Jae Sung

AU - Rohde, Charles

AU - Jasinski, Donald R

AU - Gjedde, Albert

AU - London, Edythe D

PY - 2006

Y1 - 2006

N2 - In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

AB - In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.

U2 - 10.1038/sj.npp.1301194

DO - 10.1038/sj.npp.1301194

M3 - Journal article

C2 - 16971900

SN - 0893-133X

VL - 31

SP - 2716

EP - 2727

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 12

ER -