Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations

Remko van Lutterveld; Bob Oranje; Lucija Abramovic; Anne E Willems; Marco P M Boks; Birte Y Glenthøj; René S Kahn; Iris E C Sommer

doi:http://dx.doi.org/10.1016/j.schres.2010.04.017

Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations

Remko van Lutterveld, Bob Oranje, Lucija Abramovic, Anne E Willems, Marco P M Boks, Birte Y Glenthøj, René S Kahn, Iris E C Sommer

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

31 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-May-20

Originalsprog	Engelsk
Tidsskrift	Schizophrenia Research
ISSN	0920-9964
DOI	https://doi.org/10.1016/j.schres.2010.04.017
Status	Udgivet - 2010

Bibliografisk note

Adgang til dokumentet

http://dx.doi.org/10.1016/j.schres.2010.04.017

Citationsformater

Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations. / van Lutterveld, Remko; Oranje, Bob; Abramovic, Lucija; Willems, Anne E; Boks, Marco P M; Glenthøj, Birte Y; Kahn, René S; Sommer, Iris E C.

I: Schizophrenia Research, 2010.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{31224a0089044419b5e7692a6cd44869,

title = "Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations",

abstract = "OBJECTIVE: Schizophrenia is associated with aberrant event-related potentials (ERPs) such as reductions in P300, processing negativity and mismatch negativity amplitudes. These deficits may be related to the propensity of schizophrenia patients to experience auditory verbal hallucinations (AVH). However, AVH are part of extensive and variable symptomatology in schizophrenia. For this reason non-psychotic individuals with AVH as an isolated symptom provide an excellent opportunity to investigate this relationship. METHODS: P300 waveforms, processing negativity and mismatch negativity were examined with an auditory oddball paradigm in 18 non-psychotic individuals with AVH and 18 controls. RESULTS: P300 amplitude was increased in the AVH group as compared to controls, reflecting superior effortful attention. A trend in the same direction was found for processing negativity. No significant differences were found for mismatch negativity. CONCLUSION: Contrary to our expectations, non-psychotic individuals with AVH show increased rather than decreased psychophysiological measures of effortful attention compared to healthy controls, refuting a pivotal role of decreased effortful attention in the pathophysiology of AVH.",

author = "{van Lutterveld}, Remko and Bob Oranje and Lucija Abramovic and Willems, {Anne E} and Boks, {Marco P M} and Glenth{\o}j, {Birte Y} and Kahn, {Ren{\'e} S} and Sommer, {Iris E C}",

year = "2010",

doi = "http://dx.doi.org/10.1016/j.schres.2010.04.017",

language = "English",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

}

TY - JOUR

T1 - Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations

AU - van Lutterveld, Remko

AU - Oranje, Bob

AU - Abramovic, Lucija

AU - Willems, Anne E

AU - Boks, Marco P M

AU - Glenthøj, Birte Y

AU - Kahn, René S

AU - Sommer, Iris E C

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: Schizophrenia is associated with aberrant event-related potentials (ERPs) such as reductions in P300, processing negativity and mismatch negativity amplitudes. These deficits may be related to the propensity of schizophrenia patients to experience auditory verbal hallucinations (AVH). However, AVH are part of extensive and variable symptomatology in schizophrenia. For this reason non-psychotic individuals with AVH as an isolated symptom provide an excellent opportunity to investigate this relationship. METHODS: P300 waveforms, processing negativity and mismatch negativity were examined with an auditory oddball paradigm in 18 non-psychotic individuals with AVH and 18 controls. RESULTS: P300 amplitude was increased in the AVH group as compared to controls, reflecting superior effortful attention. A trend in the same direction was found for processing negativity. No significant differences were found for mismatch negativity. CONCLUSION: Contrary to our expectations, non-psychotic individuals with AVH show increased rather than decreased psychophysiological measures of effortful attention compared to healthy controls, refuting a pivotal role of decreased effortful attention in the pathophysiology of AVH.

AB - OBJECTIVE: Schizophrenia is associated with aberrant event-related potentials (ERPs) such as reductions in P300, processing negativity and mismatch negativity amplitudes. These deficits may be related to the propensity of schizophrenia patients to experience auditory verbal hallucinations (AVH). However, AVH are part of extensive and variable symptomatology in schizophrenia. For this reason non-psychotic individuals with AVH as an isolated symptom provide an excellent opportunity to investigate this relationship. METHODS: P300 waveforms, processing negativity and mismatch negativity were examined with an auditory oddball paradigm in 18 non-psychotic individuals with AVH and 18 controls. RESULTS: P300 amplitude was increased in the AVH group as compared to controls, reflecting superior effortful attention. A trend in the same direction was found for processing negativity. No significant differences were found for mismatch negativity. CONCLUSION: Contrary to our expectations, non-psychotic individuals with AVH show increased rather than decreased psychophysiological measures of effortful attention compared to healthy controls, refuting a pivotal role of decreased effortful attention in the pathophysiology of AVH.

U2 - http://dx.doi.org/10.1016/j.schres.2010.04.017

DO - http://dx.doi.org/10.1016/j.schres.2010.04.017

M3 - Journal article

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -