Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

Andrés Bueno Venegas; Toyoaki Natsume; Masato Kanemaki; Ian D. Hickson

doi:10.1016/j.celrep.2020.107533

Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase

Andrés Bueno Venegas, Toyoaki Natsume, Masato Kanemaki, Ian D. Hickson^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

33 Citationer (Scopus)

101 Downloads (Pure)

Abstract

Venegas et al. employ an auxin-inducible degron system for different subunits of the SMC5/6 complex to interrogate the short- and long-term effects of SMC5/6 impairment in human cells. Degradation of SMC5/6’s subunits at different cell cycle stages places the essential role of the complex during S phase.

Originalsprog	Engelsk
Artikelnummer	107533
Tidsskrift	Cell Reports
Vol/bind	31
Udgave nummer	3
Antal sider	20
ISSN	2211-1247
DOI	https://doi.org/10.1016/j.celrep.2020.107533
Status	Udgivet - 2020

Adgang til dokumentet

10.1016/j.celrep.2020.107533Licens: CC BY-NC-ND

Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during InterphaseForlagets udgivne version, 4,48 MBLicens: CC BY-NC-ND

Citationsformater

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