Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Špela Šuler Baglama; Anja Trajber Horvat; Irena Peteln; Gregor Borut Ernst Jemec

doi:10.1159/000528128

Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports

Špela Šuler Baglama^*, Anja Trajber Horvat, Irena Peteln, Gregor Borut Ernst Jemec

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

14 Downloads (Pure)

Abstract

The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

Originalsprog	Engelsk
Tidsskrift	Case Reports in Dermatology
Vol/bind	14
Udgave nummer	3
Sider (fra-til)	362-367
Antal sider	6
ISSN	1662-6567
DOI	https://doi.org/10.1159/000528128
Status	Udgivet - 2022

Bibliografisk note

Funding Information:
This work was not supported by any funding.

Publisher Copyright:
© 2022 S. Karger AG. All rights reserved.

Adgang til dokumentet

10.1159/000528128Licens: CC BY-NC

FulltextForlagets udgivne version, 452 KBLicens: CC BY-NC

Citationsformater

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title = "Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel: Two Case Reports",

abstract = "The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.",

keywords = "Actinic keratoses, Carboplatin, Chemotherapy, Inflammation, Paclitaxel",

author = "Baglama, {{\v S}pela {\v S}uler} and {Trajber Horvat}, Anja and Irena Peteln and Jemec, {Gregor Borut Ernst}",

year = "2022",

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T1 - Inflammation of Actinic Keratoses Induced by Combination of Carboplatin and Paclitaxel

T2 - Two Case Reports

AU - Baglama, Špela Šuler

AU - Trajber Horvat, Anja

AU - Peteln, Irena

AU - Jemec, Gregor Borut Ernst

PY - 2022

Y1 - 2022

N2 - The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

AB - The observations of a beneficial effect of 5-fluorouracil-induced actinic keratoses (AK) inflammation led to the development of topical fluorouracil, a product registered for the management of AK. A conscientious surveillance of AK inflammation during chemotherapy may conceivably lead to the development of further drugs for treatment of AK. A number of other chemotherapeutics have thus been linked to similar reactions without ensuing development. Here, we describe two further cases linking chemotherapy with carboplatin and paclitaxel to possible anti-AK effects, identifying them as potential treatments. Whether multidrug chemotherapy leads to stronger AK inflammation or cure AK more successfully is currently unknown.

KW - Actinic keratoses

KW - Carboplatin

KW - Chemotherapy

KW - Inflammation

KW - Paclitaxel

U2 - 10.1159/000528128

DO - 10.1159/000528128

M3 - Journal article

C2 - 36655062

AN - SCOPUS:85144206258

SN - 1662-6567

VL - 14

SP - 362

EP - 367

JO - Case Reports in Dermatology

JF - Case Reports in Dermatology

IS - 3

ER -