Influence of exercise intensity on skeletal muscle blood flow, O2 extraction and O2 uptake on-kinetics

Andrew M Jones, Peter Krustrup, Daryl P Wilkerson, Nicolas J Berger, José A Calbet, Jens Bangsbo

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    32 Citationer (Scopus)

    Abstract

    Key points Following the start of low-intensity exercise in healthy humans, it has been established that the kinetics of muscle O(2) delivery is faster than, and does not limit, the kinetics of muscle O(2) uptake. Direct data are lacking, however, on the question of whether O(2) delivery might limit O(2) uptake kinetics during high-intensity exercise. In this study, we made frequent measurements of muscle blood flow, arterial-to-venous O(2) difference (a- difference) and O(2) uptake following the onset of multiple transitions of both low-intensity and high-intensity knee-extension exercise in the same subjects. We show that although blood flow kinetics is slower for high-intensity compared with low-intensity exercise, this does not result in slower O(2) uptake kinetics. These results indicate that muscle O(2) delivery does not limit O(2) uptake during knee-extension exercise in healthy humans.
    OriginalsprogEngelsk
    TidsskriftJournal of Physiology
    Vol/bind590
    Udgave nummer17
    Sider (fra-til)4363-4376
    Antal sider14
    ISSN0022-3751
    DOI
    StatusUdgivet - 2012

    Bibliografisk note

    CURIS 2012 5200 118

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