TY - JOUR
T1 - Influence of Genetics, Immunity and the Microbiome on the Prognosis of Inflammatory Bowel Disease (IBD Prognosis Study)
T2 - the protocol for a Copenhagen IBD Inception Cohort Study
AU - Attauabi, Mohamed
AU - Madsen, Gorm Roager
AU - Bendtsen, Flemming
AU - Wewer, Anne Vibeke
AU - Wilkens, Rune
AU - Ilvemark, Johan
AU - Vladimirova, Nora
AU - Jensen, Annette Bøjer
AU - Jensen, Frank Krieger
AU - Hansen, Sanja Bay
AU - Siebner, Hartwig Roman
AU - Nielsen, Yousef Jesper Wirenfeldt
AU - Møller, Jakob M
AU - Thomsen, Henrik S
AU - Thomsen, Simon Francis
AU - Ingels, Helene Andrea Sinclair
AU - Theede, Klaus
AU - Boysen, Trine
AU - Bjerrum, Jacob T
AU - Jakobsen, Christian
AU - Dorn-Rasmussen, Maria
AU - Jansson, Sabine
AU - Yao, Yiqiu
AU - Burian, Ewa Anna
AU - Møller, Frederik Trier
AU - Fana, Viktoria
AU - Wiell, Charlotte
AU - Terslev, Lene
AU - Østergaard, Mikkel
AU - Bertl, Kristina
AU - Stavropoulos, Andreas
AU - Seidelin, Jakob B
AU - Burisch, Johan
N1 - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2022
Y1 - 2022
N2 - INTRODUCTION: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.METHODS AND ANALYSIS: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.ETHICS AND DISSEMINATION: This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences.
AB - INTRODUCTION: Inflammatory bowel diseases (IBD), encompassing Crohn's disease and ulcerative colitis, are chronic, inflammatory diseases of the gastrointestinal tract. We have initiated a Danish population-based inception cohort study aiming to investigate the underlying mechanisms for the heterogeneous course of IBD, including need for, and response to, treatment.METHODS AND ANALYSIS: IBD Prognosis Study is a prospective, population-based inception cohort study of unselected, newly diagnosed adult, adolescent and paediatric patients with IBD within the uptake area of Hvidovre University Hospital and Herlev University Hospital, Denmark, which covers approximately 1 050 000 inhabitants (~20% of the Danish population). The diagnosis of IBD will be according to the Porto diagnostic criteria in paediatric and adolescent patients or the Copenhagen diagnostic criteria in adult patients. All patients will be followed prospectively with regular clinical examinations including ileocolonoscopies, MRI of the small intestine, validated patient-reported measures and objective examinations with intestinal ultrasound. In addition, intestinal biopsies from ileocolonoscopies, stool, rectal swabs, saliva samples, swabs of the oral cavity and blood samples will be collected systematically for the analysis of biomarkers, microbiome and genetic profiles. Environmental factors and quality of life will be assessed using questionnaires and, when available, automatic registration of purchase data. The occurrence and course of extraintestinal manifestations will be evaluated by rheumatologists, dermatologists and dentists, and assessed by MR cholangiopancreatography, MR of the spine and sacroiliac joints, ultrasonography of peripheral joints and entheses, clinical oral examination, as well as panoramic radiograph of the jaws. Fibroscans and dual-energy X-ray absorptiometry scans will be performed to monitor occurrence and course of chronic liver diseases, osteopenia and osteoporosis.ETHICS AND DISSEMINATION: This study has been approved by Ethics Committee of the Capital Region of Denmark (approval number: H-20065831). Study results will be disseminated through publication in international scientific journals and presentation at (inter)national conferences.
KW - Adolescent
KW - Adult
KW - Child
KW - Cohort Studies
KW - Colitis, Ulcerative/therapy
KW - Humans
KW - Inflammatory Bowel Diseases/diagnosis
KW - Microbiota
KW - Prognosis
KW - Prospective Studies
KW - Quality of Life
U2 - 10.1136/bmjopen-2021-055779
DO - 10.1136/bmjopen-2021-055779
M3 - Journal article
C2 - 35760545
VL - 12
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 6
M1 - e055779
ER -