TY - JOUR
T1 - Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids
T2 - the DiOGenes study
AU - Brahe, Lena Kirchner
AU - Angquist, Lars
AU - Larsen, Lesli Hingstrup
AU - Vimaleswaran, Karani S
AU - Hager, Jörg
AU - Viguerie, Nathalie
AU - Loos, Ruth J F
AU - Handjieva-Darlenska, Teodora
AU - Jebb, Susan A
AU - Hlavaty, Petr
AU - Larsen, Thomas Meinert
AU - Martinez, J Alfredo
AU - Papadaki, Angeliki
AU - Pfeiffer, Andreas F H
AU - van Baak, Marleen A
AU - Sørensen, Thorkild I A
AU - Holst, Claus
AU - Langin, Dominique
AU - Astrup, Arne
AU - Saris, Wim H M
N1 - CURIS 2013 NEXS 083
PY - 2013
Y1 - 2013
N2 - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.
AB - Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene-diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP-diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-month ad libitum weight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP-dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of - 0·26 mmol/l per A-allele/protein unit (95 % CI - 0·38, - 0·14, P= 0·000043). In conclusion, we investigated SNP-diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction between LPIN1 rs4315495 and dietary protein for TAG concentration.
U2 - 10.1017/S0007114512006058
DO - 10.1017/S0007114512006058
M3 - Journal article
C2 - 23360819
VL - 110
SP - 790
EP - 796
JO - British Journal of Nutrition
JF - British Journal of Nutrition
SN - 0007-1145
IS - 5
ER -