Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle

U Frandsen, J Bangsbo, Henning Langberg, B Saltin, Y Hellsten

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

47 Citationer (Scopus)

Abstract

We examined whether the formation or the release of the vasodilators adenosine, prostacyclin (PGI(2)) and potassium (K(+)) increase in skeletal muscle interstitium in response to nitric oxide synthase (NOS) inhibition. Five subjects performed one-legged knee extensor exercise at 30 W without (controls) and with prior N(G)-nitro-L-arginine methyl ester (L-NAME) infusion (4 mg/kg, intravenously). Samples from the interstitial fluid were obtained at rest, during exercise and after exercise with the microdialysis technique. Interstitial adenosine in controls increased (p0.05) to controls. The 6-keto-prostaglandin F1alpha concentration in controls was 1.17+/-0.20 ng/ml at rest and increased (p0.05) in L-NAME. The interstitial K(+) concentration in controls increased (p
OriginalsprogEngelsk
TidsskriftJournal of Vascular Research
Vol/bind37
Udgave nummer4
Sider (fra-til)297-302
Antal sider6
ISSN1018-1172
DOI
StatusUdgivet - 2000

Citationsformater