@article{16b467b8da094f21bbbc8fe958d158ed,
title = "Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation",
abstract = "Recently, evidence has emerged that small-conductance Ca(2+)-activated K(+) (SK) channels are predominantly expressed in the atria in a number of species including human. In rat, guinea pig, and rabbit ex vivo and in vivo models of atrial fibrillation (AF), we used 3 different SK channel inhibitors, UCL1684, N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA), and NS8593, to assess the hypothesis that pharmacological inhibition of SK channels is antiarrhythmic.",
keywords = "1-Naphthylamine, Acetylcholine, Action Potentials, Alkanes, Animals, Anti-Arrhythmia Agents, Atrial Fibrillation, Cardiac Pacing, Artificial, Dose-Response Relationship, Drug, Electrocardiography, Female, Guinea Pigs, Male, Myocardium, Perfusion, Potassium Channel Blockers, Potassium Channels, Calcium-Activated, Pyridines, Quinolinium Compounds, Rabbits, Rats, Rats, Sprague-Dawley, Thiazoles, Time Factors",
author = "Diness, {Jonas Goldin} and S{\o}rensen, {Ulrik S} and Nissen, {Jakob Dahl} and Baha Al-Shahib and Thomas Jespersen and Morten Grunnet and Hansen, {Rie Schultz} and Thomas Jespersen",
year = "2010",
month = aug,
doi = "10.1161/CIRCEP.110.957407",
language = "English",
volume = "3",
pages = "380--90",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams & Wilkins",
number = "4",
}