Innate immune function during antineoplastic treatment is associated with 12-months survival in non-small cell lung cancer

Heidi Ryssel, Kristian Egebjerg, Susanne Dam Nielsen, Jens Lundgren, Mette Pøhl, Seppo W. Langer, Andreas Kjaer, Sisse Rye Ostrowski, Barbara Malene Fischer*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Abstract

Introduction: The immune system has proven to be a key player in the progression as well as containment of cancer with new treatment strategies based on immunotherapy targeting this interaction. Assessing immune function could reveal critical information about the immune response to therapeutic interventions, revealing predictive biomarkers for tailored care and precision medicine. Methods: We investigated immune function in 37 patients with inoperable non-small cell lung cancer (NSCLC) undergoing treatment with PD-L1 immune checkpoint inhibitor (ICI), chemotherapy (CT) or chemo-radiotherapy (CT/RT). Blood samples before (day 0) and during therapy (day 7, 21 and 80) were investigated by a standardized immunoassay, TruCulture®. Results: Outcomes revealed a developing innate immune response induced by both immunotherapy and chemotherapy. NSCLC-patients displayed evidence of chronic innate immune activation and exhaustion prior to treatment. This pattern was particularly pronounced during treatment in patients dying within 12-months follow-up. Compared to treatment with CT, ICI demonstrated a higher ex vivo-stimulated release of proinflammatory cytokines. Discussion: These preliminary findings may pave the way for tailored treatment and immune-monitoring.

OriginalsprogEngelsk
Artikelnummer1024224
TidsskriftFrontiers in Immunology
Vol/bind13
Sider (fra-til)1-12
ISSN1664-3224
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This work was supported by the Danish National Research Foundation (grant 126).

Publisher Copyright:
Copyright © 2022 Ryssel, Egebjerg, Nielsen, Lundgren, Pøhl, Langer, Kjaer, Ostrowski and Fischer.

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