InPhocus: Current State and Challenges of Phage Research in Singapore

Navin Kumar Verma; Si Jia Tan; John Chen; Hanrong Chen; Muhammad Hafiz Ismail; Scott A Rice; Pablo Bifani; Sukumar Hariharan; Vivek Daniel Paul; Bharathi Sriram; Linh Chi Dam; Chia Ching Chan; Peiying Ho; Boon Chong Goh; Shimin Jasmine Chung; Kenneth Choon Meng Goh; Shu Hua Thong; Andrea Lay Hoon Kwa; Adam Ostrowski; Thet Tun Aung; Halimah Razali; Shermaine W. Y. Low; Mani Shankar Bhattacharyya; Hemant K. Gautam; Rajamani Lakshminarayanan; Thomas Sicheritz-Pontén; Martha R. J. Clokie; Wilfried Moreira; Maurice Adrianus Monique Van Steensel

doi:10.1089/phage.2022.29028.nkv

InPhocus: Current State and Challenges of Phage Research in Singapore

Navin Kumar Verma^*, Si Jia Tan, John Chen, Hanrong Chen, Muhammad Hafiz Ismail, Scott A Rice, Pablo Bifani, Sukumar Hariharan, Vivek Daniel Paul, Bharathi Sriram, Linh Chi Dam, Chia Ching Chan, Peiying Ho, Boon Chong Goh, Shimin Jasmine Chung, Kenneth Choon Meng Goh, Shu Hua Thong, Andrea Lay Hoon Kwa, Adam Ostrowski, Thet Tun AungHalimah Razali, Shermaine W. Y. Low, Mani Shankar Bhattacharyya, Hemant K. Gautam, Rajamani Lakshminarayanan, Thomas Sicheritz-Pontén, Martha R. J. Clokie, Wilfried Moreira, Maurice Adrianus Monique Van Steensel

^*Corresponding author af dette arbejde

Section for Hologenomics

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

81 Downloads (Pure)

Abstract

Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

Originalsprog	Engelsk
Tidsskrift	PHAGE: Therapy, Applications, and Research
Vol/bind	3
Udgave nummer	1
Sider (fra-til)	6-11
Antal sider	6
ISSN	2641-6530
DOI	https://doi.org/10.1089/phage.2022.29028.nkv
Status	Udgivet - 2022

Bibliografisk note

Publisher Copyright:
© 2022, Mary Ann Liebert, Inc., publishers 2022.

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10.1089/phage.2022.29028.nkv

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Citationsformater

Verma, N. K., Tan, S. J., Chen, J., Chen, H., Ismail, M. H., Rice, S. A., Bifani, P., Hariharan, S., Paul, V. D., Sriram, B., Dam, L. C., Chan, C. C., Ho, P., Goh, B. C., Chung, S. J., Goh, K. C. M., Thong, S. H., Kwa, A. L. H., Ostrowski, A., ... Van Steensel, M. A. M. (2022). InPhocus: Current State and Challenges of Phage Research in Singapore. PHAGE: Therapy, Applications, and Research, 3(1), 6-11. https://doi.org/10.1089/phage.2022.29028.nkv

Verma, NK, Tan, SJ, Chen, J, Chen, H, Ismail, MH, Rice, SA, Bifani, P, Hariharan, S, Paul, VD, Sriram, B, Dam, LC, Chan, CC, Ho, P, Goh, BC, Chung, SJ, Goh, KCM, Thong, SH, Kwa, ALH, Ostrowski, A, Aung, TT, Razali, H, Low, SWY, Bhattacharyya, MS, Gautam, HK, Lakshminarayanan, R, Sicheritz-Pontén, T, Clokie, MRJ, Moreira, W & Van Steensel, MAM 2022, 'InPhocus: Current State and Challenges of Phage Research in Singapore', PHAGE: Therapy, Applications, and Research, bind 3, nr. 1, s. 6-11. https://doi.org/10.1089/phage.2022.29028.nkv

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abstract = "Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion. ",

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AU - Bifani, Pablo

AU - Hariharan, Sukumar

AU - Paul, Vivek Daniel

AU - Sriram, Bharathi

AU - Dam, Linh Chi

AU - Chan, Chia Ching

AU - Ho, Peiying

AU - Goh, Boon Chong

AU - Chung, Shimin Jasmine

AU - Goh, Kenneth Choon Meng

AU - Thong, Shu Hua

AU - Kwa, Andrea Lay Hoon

AU - Ostrowski, Adam

AU - Aung, Thet Tun

AU - Razali, Halimah

AU - Low, Shermaine W. Y.

AU - Bhattacharyya, Mani Shankar

AU - Gautam, Hemant K.

AU - Lakshminarayanan, Rajamani

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AB - Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.

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KW - ectolysin

KW - filamentous phages

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