Abstract
Insulin resistance is a pathophysiological state defined by impaired responses to insulin and is a risk factor for several metabolic diseases, most notably type 2 diabetes. Insulin resistance occurs in insulin target tissues including liver, adipose and skeletal muscle. Methods such as insulin tolerance tests and hyperinsulinaemic-euglycaemic clamps permit assessment of insulin responses in specific tissues and allow the study of the progression and causes of insulin resistance. Here we detail a protocol for assessing insulin action in adipose and muscle tissues in anesthetized mice administered with insulin intravenously.
Originalsprog | Engelsk |
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Artikelnummer | e3146 |
Tidsskrift | Bio-protocol |
Vol/bind | 9 |
Udgave nummer | 2 |
Antal sider | 13 |
ISSN | 2331-8325 |
DOI | |
Status | Udgivet - 2019 |
Bibliografisk note
CURIS 2019 NEXS 050Emneord
- Det Natur- og Biovidenskabelige Fakultet