Abstract
The application of the principles of evolutionary biology into medicine was suggested long ago and is already providing insight into the ultimate causes of disease. However, a full systematic integration of medical genomics and evolutionary medicine is still missing. Here, we briefly review some cases where the combination of the two fields has proven profitable and highlight two of the main issues hindering the development of evolutionary genomic medicine as a mature field, namely the dissociation between fitness and health and the still considerable difficulties in predicting phenotypes from genotypes. We use publicly available data to illustrate both problems and conclude that new approaches are needed for evolutionary genomic medicine to overcome these obstacles.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Current Opinion in Genetics and Development |
| Vol/bind | 29 |
| Sider (fra-til) | 97-102 |
| Antal sider | 6 |
| ISSN | 0959-437X |
| DOI | |
| Status | Udgivet - 2014 |
| Udgivet eksternt | Ja |
Bibliografisk note
Funding Information:This work has been supported by the Spanish Multiple Sclerosis Network (REEM) , of the Instituto de Salud Carlos III ( RD12/0032/0011 ) to AN; by the Spanish Government Grant BFU2012-38236 to AN and by FEDER . We thank David Allen Hughes for generously reading and improving the manuscript.
Publisher Copyright:
© 2014.