Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

Steffen Ullitz Thorsen; Xiang Liu; Yachana Kataria; Thomas Mandrup-poulsen; Simranjeet Kaur; Ulla Uusitalo; Suvi M. Virtanen; Jill Norris; Marian Rewers; William Hagopian; Jimin Yang; Jin-xiong She; Beena Akolkar; Stephen S. Rich; Carin Andrén Aronsson; Åke Lernmark; Anette-gabriele Ziegler; Jorma Toppari; Jeffrey P. Krischer; Hemang M. Parikh; Christina Ellervik; Jannet Svensson; Marian Rewers; Aaron Barbour; Kimberly Bautista; Judith Baxter; Daniel Felipe-morales; Brigitte I. Frohnert; Marisa Stahl; Patricia Gesualdo; Michelle Hoffman; Rachel Karban; Edwin Liu; Alondra Munoz; Jill Norris; Holly O’donnell; Stesha Peacock; Hanan Shorrosh; Andrea Steck; Megan Stern; Kathleen Waugh; Jorma Toppari; Olli G. Simell; Annika Adamsson; Suvi Ahonen; Mari Åkerlund; Sirpa Anttila; Leena Hakola; Anne Hekkala; Daniel Agardh; Environmental Determinants of Diabetes in the Young (TEDDY) Group

doi:10.2337/dc22-1359

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

Steffen Ullitz Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup-poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi M. Virtanen, Jill Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin-xiong She, Beena Akolkar, Stephen S. Rich, Carin Andrén Aronsson, Åke Lernmark, Anette-gabriele Ziegler, Jorma Toppari, Jeffrey P. Krischer, Hemang M. ParikhChristina Ellervik, Jannet Svensson, Marian Rewers, Aaron Barbour, Kimberly Bautista, Judith Baxter, Daniel Felipe-morales, Brigitte I. Frohnert, Marisa Stahl, Patricia Gesualdo, Michelle Hoffman, Rachel Karban, Edwin Liu, Alondra Munoz, Jill Norris, Holly O’donnell, Stesha Peacock, Hanan Shorrosh, Andrea Steck, Megan Stern, Kathleen Waugh, Jorma Toppari, Olli G. Simell, Annika Adamsson, Suvi Ahonen, Mari Åkerlund, Sirpa Anttila, Leena Hakola, Anne Hekkala, Daniel Agardh, Environmental Determinants of Diabetes in the Young (TEDDY) Group

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

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Abstract

OBJECTIVE
To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.

RESULTS
We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.

CONCLUSIONS
Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.

Originalsprog	Engelsk
Tidsskrift	Diabetes Care
Vol/bind	46
Udgave nummer	5
Sider (fra-til)	1-5
ISSN	1935-5548
DOI	https://doi.org/10.2337/dc22-1359
Status	Udgivet - 2023

Adgang til dokumentet

10.2337/dc22-1359

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Citationsformater

Ullitz Thorsen, S., Liu, X., Kataria, Y., Mandrup-poulsen, T., Kaur, S., Uusitalo, U., Virtanen, S. M., Norris, J., Rewers, M., Hagopian, W., Yang, J., She, J., Akolkar, B., Rich, S. S., Aronsson, C. A., Lernmark, Å., Ziegler, A., Toppari, J., Krischer, J. P., ... Environmental Determinants of Diabetes in the Young (TEDDY) Group (2023). Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care, 46(5), 1-5. https://doi.org/10.2337/dc22-1359

Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. / Ullitz Thorsen, Steffen; Liu, Xiang; Kataria, Yachana; Mandrup-poulsen, Thomas; Kaur, Simranjeet; Uusitalo, Ulla; Virtanen, Suvi M.; Norris, Jill; Rewers, Marian; Hagopian, William; Yang, Jimin; She, Jin-xiong; Akolkar, Beena; Rich, Stephen S.; Aronsson, Carin Andrén; Lernmark, Åke; Ziegler, Anette-gabriele; Toppari, Jorma; Krischer, Jeffrey P.; Parikh, Hemang M.; Ellervik, Christina ; Svensson, Jannet; Rewers, Marian; Barbour, Aaron; Bautista, Kimberly; Baxter, Judith; Felipe-morales, Daniel; Frohnert, Brigitte I.; Stahl, Marisa; Gesualdo, Patricia; Hoffman, Michelle; Karban, Rachel; Liu, Edwin; Munoz, Alondra; Norris, Jill; O’donnell, Holly; Peacock, Stesha; Shorrosh, Hanan; Steck, Andrea; Stern, Megan; Waugh, Kathleen; Toppari, Jorma; Simell, Olli G.; Adamsson, Annika; Ahonen, Suvi; Åkerlund, Mari; Anttila, Sirpa; Hakola, Leena; Hekkala, Anne; Agardh, Daniel; Environmental Determinants of Diabetes in the Young (TEDDY) Group.

I: Diabetes Care, Bind 46, Nr. 5, 2023, s. 1-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ullitz Thorsen, S, Liu, X, Kataria, Y, Mandrup-poulsen, T, Kaur, S, Uusitalo, U, Virtanen, SM, Norris, J, Rewers, M, Hagopian, W, Yang, J, She, J, Akolkar, B, Rich, SS, Aronsson, CA, Lernmark, Å, Ziegler, A, Toppari, J, Krischer, JP, Parikh, HM, Ellervik, C , Svensson, J, Rewers, M, Barbour, A, Bautista, K, Baxter, J, Felipe-morales, D, Frohnert, BI, Stahl, M, Gesualdo, P, Hoffman, M, Karban, R, Liu, E, Munoz, A, Norris, J, O’donnell, H, Peacock, S, Shorrosh, H, Steck, A, Stern, M, Waugh, K, Toppari, J, Simell, OG, Adamsson, A, Ahonen, S, Åkerlund, M, Anttila, S, Hakola, L, Hekkala, A, Agardh, D & Environmental Determinants of Diabetes in the Young (TEDDY) Group 2023, 'Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study', Diabetes Care, bind 46, nr. 5, s. 1-5. https://doi.org/10.2337/dc22-1359

Ullitz Thorsen, Steffen ; Liu, Xiang ; Kataria, Yachana ; Mandrup-poulsen, Thomas ; Kaur, Simranjeet ; Uusitalo, Ulla ; Virtanen, Suvi M. ; Norris, Jill ; Rewers, Marian ; Hagopian, William ; Yang, Jimin ; She, Jin-xiong ; Akolkar, Beena ; Rich, Stephen S. ; Aronsson, Carin Andrén ; Lernmark, Åke ; Ziegler, Anette-gabriele ; Toppari, Jorma ; Krischer, Jeffrey P. ; Parikh, Hemang M. ; Ellervik, Christina ; Svensson, Jannet ; Rewers, Marian ; Barbour, Aaron ; Bautista, Kimberly ; Baxter, Judith ; Felipe-morales, Daniel ; Frohnert, Brigitte I. ; Stahl, Marisa ; Gesualdo, Patricia ; Hoffman, Michelle ; Karban, Rachel ; Liu, Edwin ; Munoz, Alondra ; Norris, Jill ; O’donnell, Holly ; Peacock, Stesha ; Shorrosh, Hanan ; Steck, Andrea ; Stern, Megan ; Waugh, Kathleen ; Toppari, Jorma ; Simell, Olli G. ; Adamsson, Annika ; Ahonen, Suvi ; Åkerlund, Mari ; Anttila, Sirpa ; Hakola, Leena ; Hekkala, Anne ; Agardh, Daniel ; Environmental Determinants of Diabetes in the Young (TEDDY) Group. / Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload : Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. I: Diabetes Care. 2023 ; Bind 46, Nr. 5. s. 1-5.

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title = "Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study",

abstract = "OBJECTIVETo examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.",

author = "{Ullitz Thorsen}, Steffen and Xiang Liu and Yachana Kataria and Thomas Mandrup-poulsen and Simranjeet Kaur and Ulla Uusitalo and Virtanen, {Suvi M.} and Jill Norris and Marian Rewers and William Hagopian and Jimin Yang and Jin-xiong She and Beena Akolkar and Rich, {Stephen S.} and Aronsson, {Carin Andr{\'e}n} and {\AA}ke Lernmark and Anette-gabriele Ziegler and Jorma Toppari and Krischer, {Jeffrey P.} and Parikh, {Hemang M.} and Christina Ellervik and Jannet Svensson and Marian Rewers and Aaron Barbour and Kimberly Bautista and Judith Baxter and Daniel Felipe-morales and Frohnert, {Brigitte I.} and Marisa Stahl and Patricia Gesualdo and Michelle Hoffman and Rachel Karban and Edwin Liu and Alondra Munoz and Jill Norris and Holly O{\textquoteright}donnell and Stesha Peacock and Hanan Shorrosh and Andrea Steck and Megan Stern and Kathleen Waugh and Jorma Toppari and Simell, {Olli G.} and Annika Adamsson and Suvi Ahonen and Mari {\AA}kerlund and Sirpa Anttila and Leena Hakola and Anne Hekkala and Daniel Agardh and {Environmental Determinants of Diabetes in the Young (TEDDY) Group}",

year = "2023",

doi = "10.2337/dc22-1359",

language = "English",

volume = "46",

pages = "1--5",

journal = "Diabetes Care",

issn = "1935-5548",

publisher = "American Diabetes Association",

number = "5",

}

TY - JOUR

T1 - Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload

T2 - Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

AU - Ullitz Thorsen, Steffen

AU - Liu, Xiang

AU - Kataria, Yachana

AU - Mandrup-poulsen, Thomas

AU - Kaur, Simranjeet

AU - Uusitalo, Ulla

AU - Virtanen, Suvi M.

AU - Norris, Jill

AU - Rewers, Marian

AU - Hagopian, William

AU - Yang, Jimin

AU - She, Jin-xiong

AU - Akolkar, Beena

AU - Rich, Stephen S.

AU - Aronsson, Carin Andrén

AU - Lernmark, Åke

AU - Ziegler, Anette-gabriele

AU - Toppari, Jorma

AU - Krischer, Jeffrey P.

AU - Parikh, Hemang M.

AU - Ellervik, Christina

AU - Svensson, Jannet

AU - Rewers, Marian

AU - Barbour, Aaron

AU - Bautista, Kimberly

AU - Baxter, Judith

AU - Felipe-morales, Daniel

AU - Frohnert, Brigitte I.

AU - Stahl, Marisa

AU - Gesualdo, Patricia

AU - Hoffman, Michelle

AU - Karban, Rachel

AU - Liu, Edwin

AU - Munoz, Alondra

AU - Norris, Jill

AU - O’donnell, Holly

AU - Peacock, Stesha

AU - Shorrosh, Hanan

AU - Steck, Andrea

AU - Stern, Megan

AU - Waugh, Kathleen

AU - Toppari, Jorma

AU - Simell, Olli G.

AU - Adamsson, Annika

AU - Ahonen, Suvi

AU - Åkerlund, Mari

AU - Anttila, Sirpa

AU - Hakola, Leena

AU - Hekkala, Anne

AU - Agardh, Daniel

AU - Environmental Determinants of Diabetes in the Young (TEDDY) Group

PY - 2023

Y1 - 2023

N2 - OBJECTIVETo examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.

AB - OBJECTIVETo examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).RESEARCH DESIGN AND METHODSIn The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.RESULTSWe found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.CONCLUSIONSIron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.

U2 - 10.2337/dc22-1359

DO - 10.2337/dc22-1359

M3 - Journal article

C2 - 36867433

VL - 46

SP - 1

EP - 5

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 5

ER -