Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Nadeem Sarwar; Adam S Butterworth; Daniel F Freitag; John Gregson; Peter Willeit; Donal N Gorman; Pei Gao; Danish Saleheen; Augusto Rendon; Christopher P Nelson; Peter S Braund; Alistair S Hall; Daniel I Chasman; Anne Tybjærg-Hansen; John C Chambers; Emelia J Benjamin; Paul W Franks; Robert Clarke; Arthur A M Wilde; Mieke D Trip; Maristella Steri; Jacqueline C M Witteman; Lu Qi; C Ellen van der Schoot; Ulf de Faire; Jeanette Erdmann; Heather M Stringham; Wolfgang Koenig; Daniel J Rader; David Melzer; David Reich; Bruce M Psaty; Marcus E Kleber; Demosthenes B Panagiotakos; Johann Willeit; Patrik Wennberg; Mark Woodward; Svetlana Adamovic; Eric B Rimm; Tom W Meade; Richard F Gillum; Jonathan A Shaffer; Albert Hofman; Altan Onat; Johan Sundström; Sylvia Wassertheil-Smoller; Dan Mellström; John Gallacher; Kristine Højgaard Allin; Børge G Nordestgaard; IL6R Genetics Consortium Emerging Risk Factors Collaboration

doi:10.1016/S0140-6736(11)61931-4

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

Nadeem Sarwar, Adam S Butterworth, Daniel F Freitag, John Gregson, Peter Willeit, Donal N Gorman, Pei Gao, Danish Saleheen, Augusto Rendon, Christopher P Nelson, Peter S Braund, Alistair S Hall, Daniel I Chasman, Anne Tybjærg-Hansen, John C Chambers, Emelia J Benjamin, Paul W Franks, Robert Clarke, Arthur A M Wilde, Mieke D TripMaristella Steri, Jacqueline C M Witteman, Lu Qi, C Ellen van der Schoot, Ulf de Faire, Jeanette Erdmann, Heather M Stringham, Wolfgang Koenig, Daniel J Rader, David Melzer, David Reich, Bruce M Psaty, Marcus E Kleber, Demosthenes B Panagiotakos, Johann Willeit, Patrik Wennberg, Mark Woodward, Svetlana Adamovic, Eric B Rimm, Tom W Meade, Richard F Gillum, Jonathan A Shaffer, Albert Hofman, Altan Onat, Johan Sundström, Sylvia Wassertheil-Smoller, Dan Mellström, John Gallacher, Kristine Højgaard Allin, Børge G Nordestgaard, IL6R Genetics Consortium Emerging Risk Factors Collaboration

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

661 Citationer (Scopus)

Abstract

Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

Originalsprog	Engelsk
Tidsskrift	Lancet
Vol/bind	379
Udgave nummer	9822
Sider (fra-til)	1205-13
Antal sider	9
ISSN	0140-6736
DOI	https://doi.org/10.1016/S0140-6736(11)61931-4
Status	Udgivet - 31 mar. 2012

Adgang til dokumentet

10.1016/S0140-6736(11)61931-4

Citationsformater

Sarwar, N., Butterworth, A. S., Freitag, D. F., Gregson, J., Willeit, P., Gorman, D. N., Gao, P., Saleheen, D., Rendon, A., Nelson, C. P., Braund, P. S., Hall, A. S., Chasman, D. I., Tybjærg-Hansen, A., Chambers, J. C., Benjamin, E. J., Franks, P. W., Clarke, R., Wilde, A. A. M., ... IL6R Genetics Consortium Emerging Risk Factors Collaboration (2012). Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet, 379(9822), 1205-13. https://doi.org/10.1016/S0140-6736(11)61931-4

Interleukin-6 receptor pathways in coronary heart disease : a collaborative meta-analysis of 82 studies. / Sarwar, Nadeem; Butterworth, Adam S; Freitag, Daniel F; Gregson, John; Willeit, Peter; Gorman, Donal N; Gao, Pei; Saleheen, Danish; Rendon, Augusto; Nelson, Christopher P; Braund, Peter S; Hall, Alistair S; Chasman, Daniel I; Tybjærg-Hansen, Anne; Chambers, John C; Benjamin, Emelia J; Franks, Paul W; Clarke, Robert; Wilde, Arthur A M; Trip, Mieke D; Steri, Maristella; Witteman, Jacqueline C M; Qi, Lu; van der Schoot, C Ellen; de Faire, Ulf; Erdmann, Jeanette; Stringham, Heather M; Koenig, Wolfgang; Rader, Daniel J; Melzer, David; Reich, David; Psaty, Bruce M; Kleber, Marcus E; Panagiotakos, Demosthenes B; Willeit, Johann; Wennberg, Patrik; Woodward, Mark; Adamovic, Svetlana; Rimm, Eric B; Meade, Tom W; Gillum, Richard F; Shaffer, Jonathan A; Hofman, Albert; Onat, Altan; Sundström, Johan; Wassertheil-Smoller, Sylvia; Mellström, Dan; Gallacher, John; Allin, Kristine Højgaard; Nordestgaard, Børge G; IL6R Genetics Consortium Emerging Risk Factors Collaboration.

I: Lancet, Bind 379, Nr. 9822, 31.03.2012, s. 1205-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sarwar, N, Butterworth, AS, Freitag, DF, Gregson, J, Willeit, P, Gorman, DN, Gao, P, Saleheen, D, Rendon, A, Nelson, CP, Braund, PS, Hall, AS, Chasman, DI, Tybjærg-Hansen, A, Chambers, JC, Benjamin, EJ, Franks, PW, Clarke, R, Wilde, AAM, Trip, MD, Steri, M, Witteman, JCM, Qi, L, van der Schoot, CE, de Faire, U, Erdmann, J, Stringham, HM, Koenig, W, Rader, DJ, Melzer, D, Reich, D, Psaty, BM, Kleber, ME, Panagiotakos, DB, Willeit, J, Wennberg, P, Woodward, M, Adamovic, S, Rimm, EB, Meade, TW, Gillum, RF, Shaffer, JA, Hofman, A, Onat, A, Sundström, J, Wassertheil-Smoller, S, Mellström, D, Gallacher, J, Allin, KH, Nordestgaard, BG & IL6R Genetics Consortium Emerging Risk Factors Collaboration 2012, 'Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies', Lancet, bind 379, nr. 9822, s. 1205-13. https://doi.org/10.1016/S0140-6736(11)61931-4

Sarwar, Nadeem ; Butterworth, Adam S ; Freitag, Daniel F ; Gregson, John ; Willeit, Peter ; Gorman, Donal N ; Gao, Pei ; Saleheen, Danish ; Rendon, Augusto ; Nelson, Christopher P ; Braund, Peter S ; Hall, Alistair S ; Chasman, Daniel I ; Tybjærg-Hansen, Anne ; Chambers, John C ; Benjamin, Emelia J ; Franks, Paul W ; Clarke, Robert ; Wilde, Arthur A M ; Trip, Mieke D ; Steri, Maristella ; Witteman, Jacqueline C M ; Qi, Lu ; van der Schoot, C Ellen ; de Faire, Ulf ; Erdmann, Jeanette ; Stringham, Heather M ; Koenig, Wolfgang ; Rader, Daniel J ; Melzer, David ; Reich, David ; Psaty, Bruce M ; Kleber, Marcus E ; Panagiotakos, Demosthenes B ; Willeit, Johann ; Wennberg, Patrik ; Woodward, Mark ; Adamovic, Svetlana ; Rimm, Eric B ; Meade, Tom W ; Gillum, Richard F ; Shaffer, Jonathan A ; Hofman, Albert ; Onat, Altan ; Sundström, Johan ; Wassertheil-Smoller, Sylvia ; Mellström, Dan ; Gallacher, John ; Allin, Kristine Højgaard ; Nordestgaard, Børge G ; IL6R Genetics Consortium Emerging Risk Factors Collaboration. / Interleukin-6 receptor pathways in coronary heart disease : a collaborative meta-analysis of 82 studies. I: Lancet. 2012 ; Bind 379, Nr. 9822. s. 1205-13.

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abstract = "Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.",

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T1 - Interleukin-6 receptor pathways in coronary heart disease

T2 - a collaborative meta-analysis of 82 studies

AU - Sarwar, Nadeem

AU - Butterworth, Adam S

AU - Freitag, Daniel F

AU - Gregson, John

AU - Willeit, Peter

AU - Gorman, Donal N

AU - Gao, Pei

AU - Saleheen, Danish

AU - Rendon, Augusto

AU - Nelson, Christopher P

AU - Braund, Peter S

AU - Hall, Alistair S

AU - Chasman, Daniel I

AU - Tybjærg-Hansen, Anne

AU - Chambers, John C

AU - Benjamin, Emelia J

AU - Franks, Paul W

AU - Clarke, Robert

AU - Wilde, Arthur A M

AU - Trip, Mieke D

AU - Steri, Maristella

AU - Witteman, Jacqueline C M

AU - Qi, Lu

AU - van der Schoot, C Ellen

AU - de Faire, Ulf

AU - Erdmann, Jeanette

AU - Stringham, Heather M

AU - Koenig, Wolfgang

AU - Rader, Daniel J

AU - Melzer, David

AU - Reich, David

AU - Psaty, Bruce M

AU - Kleber, Marcus E

AU - Panagiotakos, Demosthenes B

AU - Willeit, Johann

AU - Wennberg, Patrik

AU - Woodward, Mark

AU - Adamovic, Svetlana

AU - Rimm, Eric B

AU - Meade, Tom W

AU - Gillum, Richard F

AU - Shaffer, Jonathan A

AU - Hofman, Albert

AU - Onat, Altan

AU - Sundström, Johan

AU - Wassertheil-Smoller, Sylvia

AU - Mellström, Dan

AU - Gallacher, John

AU - Allin, Kristine Højgaard

AU - Nordestgaard, Børge G

AU - IL6R Genetics Consortium Emerging Risk Factors Collaboration

PY - 2012/3/31

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N2 - Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

AB - Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.

KW - Causality

KW - Coronary Disease

KW - Gene Frequency

KW - Genetic Variation

KW - Humans

KW - Inflammation Mediators

KW - Receptors, Interleukin-6

KW - Risk Factors

KW - Signal Transduction

U2 - 10.1016/S0140-6736(11)61931-4

DO - 10.1016/S0140-6736(11)61931-4

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VL - 379

SP - 1205

EP - 1213

JO - The Lancet

JF - The Lancet

SN - 0140-6736

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ER -