Interleukin-6 stimulates lipolysis and fat oxidation in humans.

Gerrit van Hall; Adam Steensberg; Massimo Sacchetti; Christian Fischer; Charlotte Keller; Peter Schjerling; Natalie Hiscock; Kirsten Møller; Bengt Saltin; Mark A Febbraio; Bente K Pedersen

Interleukin-6 stimulates lipolysis and fat oxidation in humans.

Gerrit van Hall, Adam Steensberg, Massimo Sacchetti, Christian Fischer, Charlotte Keller, Peter Schjerling, Natalie Hiscock, Kirsten Møller, Bengt Saltin, Mark A Febbraio, Bente K Pedersen

Exercise and Muscle

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

613 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Jul

Originalsprog	Engelsk
Tidsskrift	Journal of Clinical Endocrinology and Metabolism
Vol/bind	88
Udgave nummer	7
Sider (fra-til)	3005-10
Antal sider	5
ISSN	0021-972X
Status	Udgivet - 2003

Bibliografisk note

Keywords: Adult; Energy Metabolism; Epinephrine; Fatty Acids; Glucagon; Glycerol; Humans; Hydrocortisone; Insulin; Interleukin-6; Lipolysis; Male; Norepinephrine; Oxidation-Reduction; Oxygen Consumption; Recombinant Proteins; Triglycerides

Citationsformater

@article{bc6c93c0ac0111ddb5e9000ea68e967b,

title = "Interleukin-6 stimulates lipolysis and fat oxidation in humans.",

abstract = "Although IL-6 is a key modulator of immune function, it also plays a role in regulating substrate metabolism. To determine whether IL-6 affects lipid metabolism, 18 healthy men were infused for 3 h with saline (Con; n = 6) or a high dose (High-rhIL6; n = 6) or a low dose (Low-rhIL6; n = 6) of recombinant human IL-6 (rhIL-6). The IL-6 concentration during Con, Low-rhIL6, and High-rhIL6 was at a steady state after 30 min of infusion at approximately 4, 140, and 320 pg/ml, respectively. Either dose of rhIL-6 was associated with a similar increase in fatty acid (FA) concentration and endogenous FA rate of appearance (R(a)) from 90 min after the start of the infusion. The FA concentration and FA R(a) continued to increase until the cessation of rhIL-6 infusion, reaching levels approximately 50% greater than Con values. The elevated levels reached at the end of rhIL-6 infusion persisted at least 3 h postinfusion. Triacylglycerol concentrations were unchanged during rhIL-6 infusion, whereas whole body fat oxidation increased after the second hour of rhIL-6 infusion. Of note, during Low-rhIL6, the induced elevation in FA concentration and FA R(a) occurred in the absence of any change in adrenaline, insulin, or glucagon, and no adverse side effects were observed. In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.",

author = "{van Hall}, Gerrit and Adam Steensberg and Massimo Sacchetti and Christian Fischer and Charlotte Keller and Peter Schjerling and Natalie Hiscock and Kirsten M{\o}ller and Bengt Saltin and Febbraio, {Mark A} and Pedersen, {Bente K}",

note = "Keywords: Adult; Energy Metabolism; Epinephrine; Fatty Acids; Glucagon; Glycerol; Humans; Hydrocortisone; Insulin; Interleukin-6; Lipolysis; Male; Norepinephrine; Oxidation-Reduction; Oxygen Consumption; Recombinant Proteins; Triglycerides",

year = "2003",

language = "English",

volume = "88",

pages = "3005--10",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Oxford University Press",

number = "7",

}

TY - JOUR

T1 - Interleukin-6 stimulates lipolysis and fat oxidation in humans.

AU - van Hall, Gerrit

AU - Steensberg, Adam

AU - Sacchetti, Massimo

AU - Fischer, Christian

AU - Keller, Charlotte

AU - Schjerling, Peter

AU - Hiscock, Natalie

AU - Møller, Kirsten

AU - Saltin, Bengt

AU - Febbraio, Mark A

AU - Pedersen, Bente K

N1 - Keywords: Adult; Energy Metabolism; Epinephrine; Fatty Acids; Glucagon; Glycerol; Humans; Hydrocortisone; Insulin; Interleukin-6; Lipolysis; Male; Norepinephrine; Oxidation-Reduction; Oxygen Consumption; Recombinant Proteins; Triglycerides

PY - 2003

Y1 - 2003

N2 - Although IL-6 is a key modulator of immune function, it also plays a role in regulating substrate metabolism. To determine whether IL-6 affects lipid metabolism, 18 healthy men were infused for 3 h with saline (Con; n = 6) or a high dose (High-rhIL6; n = 6) or a low dose (Low-rhIL6; n = 6) of recombinant human IL-6 (rhIL-6). The IL-6 concentration during Con, Low-rhIL6, and High-rhIL6 was at a steady state after 30 min of infusion at approximately 4, 140, and 320 pg/ml, respectively. Either dose of rhIL-6 was associated with a similar increase in fatty acid (FA) concentration and endogenous FA rate of appearance (R(a)) from 90 min after the start of the infusion. The FA concentration and FA R(a) continued to increase until the cessation of rhIL-6 infusion, reaching levels approximately 50% greater than Con values. The elevated levels reached at the end of rhIL-6 infusion persisted at least 3 h postinfusion. Triacylglycerol concentrations were unchanged during rhIL-6 infusion, whereas whole body fat oxidation increased after the second hour of rhIL-6 infusion. Of note, during Low-rhIL6, the induced elevation in FA concentration and FA R(a) occurred in the absence of any change in adrenaline, insulin, or glucagon, and no adverse side effects were observed. In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.

AB - Although IL-6 is a key modulator of immune function, it also plays a role in regulating substrate metabolism. To determine whether IL-6 affects lipid metabolism, 18 healthy men were infused for 3 h with saline (Con; n = 6) or a high dose (High-rhIL6; n = 6) or a low dose (Low-rhIL6; n = 6) of recombinant human IL-6 (rhIL-6). The IL-6 concentration during Con, Low-rhIL6, and High-rhIL6 was at a steady state after 30 min of infusion at approximately 4, 140, and 320 pg/ml, respectively. Either dose of rhIL-6 was associated with a similar increase in fatty acid (FA) concentration and endogenous FA rate of appearance (R(a)) from 90 min after the start of the infusion. The FA concentration and FA R(a) continued to increase until the cessation of rhIL-6 infusion, reaching levels approximately 50% greater than Con values. The elevated levels reached at the end of rhIL-6 infusion persisted at least 3 h postinfusion. Triacylglycerol concentrations were unchanged during rhIL-6 infusion, whereas whole body fat oxidation increased after the second hour of rhIL-6 infusion. Of note, during Low-rhIL6, the induced elevation in FA concentration and FA R(a) occurred in the absence of any change in adrenaline, insulin, or glucagon, and no adverse side effects were observed. In conclusion, the data identify IL-6 as a potent modulator of fat metabolism in humans, increasing fat oxidation and FA reesterification without causing hypertriacylglyceridemia.

M3 - Journal article

C2 - 12843134

SN - 0021-972X

VL - 88

SP - 3005

EP - 3010

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 7

ER -