Interleukin-8 production from human somatotroph adenoma cells is stimulated by interleukin-1β and inhibited by growth hormone releasing hormone and somatostatin

Signe Diness Vindeløv, Marie-Louise Hartoft-Nielsen, Åse Krogh Rasmussen, Klaus Bendtzen, Michael Kosteljanetz, Anna-Maria Andersson, Ulla Feldt-Rasmussen

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    Abstract

    Pituitary adenomas cause morbidity and mortality due to their localization and influence on pituitary hormone secretion. Although the pathogenesis of pituitary adenomas is unclear, studies have indicated that cytokines are involved. We investigated the role of cytokines, in particular interleukin (IL)-8, in the pathogenesis of growth hormone (GH) producing tumours.
    OriginalsprogEngelsk
    TidsskriftGrowth Hormone & IGF Research
    Vol/bind21
    Udgave nummer3
    Sider (fra-til)134-9
    Antal sider6
    ISSN1096-6374
    DOI
    StatusUdgivet - 2011

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