Intraoperative immunohistochemistry staining of sentinel nodes in breast cancer: Clinical and economical implications

M. Holm; B. Paaschburg; E. Balslev; C.K. Axelsson; G.L. Willemoe; Henrik Lavlund Flyger

Intraoperative immunohistochemistry staining of sentinel nodes in breast cancer: Clinical and economical implications

M. Holm, B. Paaschburg, E. Balslev, C.K. Axelsson, G.L. Willemoe, Henrik Lavlund Flyger

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

The study aimed to evaluate intraoperative immunohistochemistry (IHC) staining of sentinel nodes in primary breast cancer surgery. We analysed retrospectively 1209 consecutive sentinel node procedures and compared the rate of late positive metastases in sentinel node biopsy (SNB) and the duration of the surgical procedures before (n = 706) and after (n = 503) introducing intraoperatice IHC on frozen section. We also did a cost analysis. Intraoperative IHC staining led to a lowering of the late positive SNB rate. Introducing IHC gave a decrease in the late positive rate from 93 to 52% (p < 0.0001) for isolated tumor cell metastasis, from 56 to 36.4% (p < 0.02) for micrometastasis, and from 16 to 5% (p < 0.01) for macrometastasis. The surgical procedures were slightly prolonged for lumpectomies but not for mastectomies after introducing intraoperative IHC staining. The cost analysis showed an overall cost saving of approximately 40%. In conclusion, intraoperative IHC staining of the SNB lowered the late positive rate and gave an overall cost saving. (c) 2008 Elsevier Ltd. All rights reserved
Udgivelsesdato: 2008/8

Originalsprog	Engelsk
Tidsskrift	Breast
Vol/bind	17
Udgave nummer	4
Sider (fra-til)	372-375
Antal sider	3
ISSN	0960-9776
Status	Udgivet - 2008

Bibliografisk note

Times Cited: 0ArticleEnglishHolm, MUniv Copenhagen, Herlev Hosp, Dept Breast Surg, Herlev Ringvej 75, DK-2730 Herlev, DenmarkCited References Count: 18355LWCHURCHILL LIVINGSTONEJOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLANDEDINBURGH

Citationsformater

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title = "Intraoperative immunohistochemistry staining of sentinel nodes in breast cancer: Clinical and economical implications",

abstract = "The study aimed to evaluate intraoperative immunohistochemistry (IHC) staining of sentinel nodes in primary breast cancer surgery. We analysed retrospectively 1209 consecutive sentinel node procedures and compared the rate of late positive metastases in sentinel node biopsy (SNB) and the duration of the surgical procedures before (n = 706) and after (n = 503) introducing intraoperatice IHC on frozen section. We also did a cost analysis. Intraoperative IHC staining led to a lowering of the late positive SNB rate. Introducing IHC gave a decrease in the late positive rate from 93 to 52% (p < 0.0001) for isolated tumor cell metastasis, from 56 to 36.4% (p < 0.02) for micrometastasis, and from 16 to 5% (p < 0.01) for macrometastasis. The surgical procedures were slightly prolonged for lumpectomies but not for mastectomies after introducing intraoperative IHC staining. The cost analysis showed an overall cost saving of approximately 40%. In conclusion, intraoperative IHC staining of the SNB lowered the late positive rate and gave an overall cost saving. (c) 2008 Elsevier Ltd. All rights reserved Udgivelsesdato: 2008/8",

author = "M. Holm and B. Paaschburg and E. Balslev and C.K. Axelsson and G.L. Willemoe and Flyger, {Henrik Lavlund}",

note = "Times Cited: 0ArticleEnglishHolm, MUniv Copenhagen, Herlev Hosp, Dept Breast Surg, Herlev Ringvej 75, DK-2730 Herlev, DenmarkCited References Count: 18355LWCHURCHILL LIVINGSTONEJOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLANDEDINBURGH",

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TY - JOUR

T1 - Intraoperative immunohistochemistry staining of sentinel nodes in breast cancer: Clinical and economical implications

AU - Holm, M.

AU - Paaschburg, B.

AU - Balslev, E.

AU - Axelsson, C.K.

AU - Willemoe, G.L.

AU - Flyger, Henrik Lavlund

N1 - Times Cited: 0ArticleEnglishHolm, MUniv Copenhagen, Herlev Hosp, Dept Breast Surg, Herlev Ringvej 75, DK-2730 Herlev, DenmarkCited References Count: 18355LWCHURCHILL LIVINGSTONEJOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLANDEDINBURGH

PY - 2008

Y1 - 2008

N2 - The study aimed to evaluate intraoperative immunohistochemistry (IHC) staining of sentinel nodes in primary breast cancer surgery. We analysed retrospectively 1209 consecutive sentinel node procedures and compared the rate of late positive metastases in sentinel node biopsy (SNB) and the duration of the surgical procedures before (n = 706) and after (n = 503) introducing intraoperatice IHC on frozen section. We also did a cost analysis. Intraoperative IHC staining led to a lowering of the late positive SNB rate. Introducing IHC gave a decrease in the late positive rate from 93 to 52% (p < 0.0001) for isolated tumor cell metastasis, from 56 to 36.4% (p < 0.02) for micrometastasis, and from 16 to 5% (p < 0.01) for macrometastasis. The surgical procedures were slightly prolonged for lumpectomies but not for mastectomies after introducing intraoperative IHC staining. The cost analysis showed an overall cost saving of approximately 40%. In conclusion, intraoperative IHC staining of the SNB lowered the late positive rate and gave an overall cost saving. (c) 2008 Elsevier Ltd. All rights reserved Udgivelsesdato: 2008/8

AB - The study aimed to evaluate intraoperative immunohistochemistry (IHC) staining of sentinel nodes in primary breast cancer surgery. We analysed retrospectively 1209 consecutive sentinel node procedures and compared the rate of late positive metastases in sentinel node biopsy (SNB) and the duration of the surgical procedures before (n = 706) and after (n = 503) introducing intraoperatice IHC on frozen section. We also did a cost analysis. Intraoperative IHC staining led to a lowering of the late positive SNB rate. Introducing IHC gave a decrease in the late positive rate from 93 to 52% (p < 0.0001) for isolated tumor cell metastasis, from 56 to 36.4% (p < 0.02) for micrometastasis, and from 16 to 5% (p < 0.01) for macrometastasis. The surgical procedures were slightly prolonged for lumpectomies but not for mastectomies after introducing intraoperative IHC staining. The cost analysis showed an overall cost saving of approximately 40%. In conclusion, intraoperative IHC staining of the SNB lowered the late positive rate and gave an overall cost saving. (c) 2008 Elsevier Ltd. All rights reserved Udgivelsesdato: 2008/8

M3 - Journal article

SN - 0960-9776

VL - 17

SP - 372

EP - 375

JO - Breast

JF - Breast

IS - 4

ER -