Abstract
Significance
This third biennial intraoperative molecular imaging (IMI) conference shows how optical contrast agents have been applied to develop clinically significant endpoints that improve precision cancer surgery.
Aim
National and international experts on IMI presented ongoing clinical trials in cancer surgery and preclinical work. Previously known dyes (with broader applications), new dyes, novel nonfluorescence-based imaging techniques, pediatric dyes, and normal tissue dyes were discussed.
Approach
Principal investigators presenting at the Perelman School of Medicine Abramson Cancer Center’s third clinical trials update on IMI were selected to discuss their clinical trials and endpoints.
Results
Dyes that are FDA-approved or currently under clinical investigation in phase 1, 2, and 3 trials were discussed. Sections on how to move benchwork research to the bedside were also included. There was also a dedicated section for pediatric dyes and nonfluorescence-based dyes that have been newly developed.
Conclusions
IMI is a valuable adjunct in precision cancer surgery and has broad applications in multiple subspecialties. It has been reliably used to alter the surgical course of patients and in clinical decision making. There remain gaps in the utilization of IMI in certain subspecialties and potential for developing newer and improved dyes and imaging techniques.
This third biennial intraoperative molecular imaging (IMI) conference shows how optical contrast agents have been applied to develop clinically significant endpoints that improve precision cancer surgery.
Aim
National and international experts on IMI presented ongoing clinical trials in cancer surgery and preclinical work. Previously known dyes (with broader applications), new dyes, novel nonfluorescence-based imaging techniques, pediatric dyes, and normal tissue dyes were discussed.
Approach
Principal investigators presenting at the Perelman School of Medicine Abramson Cancer Center’s third clinical trials update on IMI were selected to discuss their clinical trials and endpoints.
Results
Dyes that are FDA-approved or currently under clinical investigation in phase 1, 2, and 3 trials were discussed. Sections on how to move benchwork research to the bedside were also included. There was also a dedicated section for pediatric dyes and nonfluorescence-based dyes that have been newly developed.
Conclusions
IMI is a valuable adjunct in precision cancer surgery and has broad applications in multiple subspecialties. It has been reliably used to alter the surgical course of patients and in clinical decision making. There remain gaps in the utilization of IMI in certain subspecialties and potential for developing newer and improved dyes and imaging techniques.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 050901 |
| Tidsskrift | Journal of Biomedical Optics |
| Vol/bind | 28 |
| Udgave nummer | 5 |
| Antal sider | 33 |
| ISSN | 1083-3668 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:Jane Skjøth-Rasmussen: Jane Skjoeth-Rasmussen has received consultancy fee from FluoGuide in conjunction with a first in human trial and the Department of Neurosurgery received reimbursement for the additional examinations and time. Disclosure of funding: Funding was received by Life Science Innovation North Denmark and Læge Sofus Carl Emil Friis og Hustru Olga Doris Friis Legat and partly funded by the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 954904.
Publisher Copyright:
© The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.