Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Proceedings of the National Academy of Science of the United States of America |
| Vol/bind | 105 |
| Udgave nummer | 24 |
| Sider (fra-til) | 8327-32 |
| Antal sider | 5 |
| ISSN | 0027-8424 |
| DOI | |
| Status | Udgivet - 2008 |
Bibliografisk note
Keywords: Animals; Base Sequence; DNA, Mitochondrial; Elephants; Genetic Variation; Genome, Mitochondrial; Hair; Molecular Sequence Data; Paleontology; Phylogeny; Sequence Analysis, DNAAdgang til dokumentet
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Intraspecific phylogenetic analysis of Siberian woolly mammoths using complete mitochondrial genomes. / Gilbert, M Thomas P; Drautz, Daniela I; Lesk, Arthur M; Ho, Simon Y W; Qi, Ji; Ratan, Aakrosh; Hsu, Chih-Hao; Sher, Andrei; Dalén, Love; Götherström, Anders; Tomsho, Lynn P; Rendulic, Snjezana; Packard, Michael; Campos, Paula F; Kuznetsova, Tatyana V; Shidlovskiy, Fyodor; Tikhonov, Alexei; Willerslev, Eske; Iacumin, Paola; Buigues, Bernard; Ericson, Per G P; Germonpré, Mietje; Kosintsev, Pavel; Nikolaev, Vladimir; Nowak-Kemp, Malgosia; Knight, James R; Irzyk, Gerard P; Perbost, Clotilde S; Fredrikson, Karin M; Harkins, Timothy T; Sheridan, Sharon; Miller, Webb; Schuster, Stephan C.
I: Proceedings of the National Academy of Science of the United States of America, Bind 105, Nr. 24, 2008, s. 8327-32.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Intraspecific phylogenetic analysis of Siberian woolly mammoths using complete mitochondrial genomes
AU - Gilbert, M Thomas P
AU - Drautz, Daniela I
AU - Lesk, Arthur M
AU - Ho, Simon Y W
AU - Qi, Ji
AU - Ratan, Aakrosh
AU - Hsu, Chih-Hao
AU - Sher, Andrei
AU - Dalén, Love
AU - Götherström, Anders
AU - Tomsho, Lynn P
AU - Rendulic, Snjezana
AU - Packard, Michael
AU - Campos, Paula F
AU - Kuznetsova, Tatyana V
AU - Shidlovskiy, Fyodor
AU - Tikhonov, Alexei
AU - Willerslev, Eske
AU - Iacumin, Paola
AU - Buigues, Bernard
AU - Ericson, Per G P
AU - Germonpré, Mietje
AU - Kosintsev, Pavel
AU - Nikolaev, Vladimir
AU - Nowak-Kemp, Malgosia
AU - Knight, James R
AU - Irzyk, Gerard P
AU - Perbost, Clotilde S
AU - Fredrikson, Karin M
AU - Harkins, Timothy T
AU - Sheridan, Sharon
AU - Miller, Webb
AU - Schuster, Stephan C
N1 - Keywords: Animals; Base Sequence; DNA, Mitochondrial; Elephants; Genetic Variation; Genome, Mitochondrial; Hair; Molecular Sequence Data; Paleontology; Phylogeny; Sequence Analysis, DNA
PY - 2008
Y1 - 2008
N2 - We report five new complete mitochondrial DNA (mtDNA) genomes of Siberian woolly mammoth (Mammuthus primigenius), sequenced with up to 73-fold coverage from DNA extracted from hair shaft material. Three of the sequences present the first complete mtDNA genomes of mammoth clade II. Analysis of these and 13 recently published mtDNA genomes demonstrates the existence of two apparently sympatric mtDNA clades that exhibit high interclade divergence. The analytical power afforded by the analysis of the complete mtDNA genomes reveals a surprisingly ancient coalescence age of the two clades, approximately 1-2 million years, depending on the calibration technique. Furthermore, statistical analysis of the temporal distribution of the (14)C ages of these and previously identified members of the two mammoth clades suggests that clade II went extinct before clade I. Modeling of protein structures failed to indicate any important functional difference between genomes belonging to the two clades, suggesting that the loss of clade II more likely is due to genetic drift than a selective sweep.
AB - We report five new complete mitochondrial DNA (mtDNA) genomes of Siberian woolly mammoth (Mammuthus primigenius), sequenced with up to 73-fold coverage from DNA extracted from hair shaft material. Three of the sequences present the first complete mtDNA genomes of mammoth clade II. Analysis of these and 13 recently published mtDNA genomes demonstrates the existence of two apparently sympatric mtDNA clades that exhibit high interclade divergence. The analytical power afforded by the analysis of the complete mtDNA genomes reveals a surprisingly ancient coalescence age of the two clades, approximately 1-2 million years, depending on the calibration technique. Furthermore, statistical analysis of the temporal distribution of the (14)C ages of these and previously identified members of the two mammoth clades suggests that clade II went extinct before clade I. Modeling of protein structures failed to indicate any important functional difference between genomes belonging to the two clades, suggesting that the loss of clade II more likely is due to genetic drift than a selective sweep.
U2 - 10.1073/pnas.0802315105
DO - 10.1073/pnas.0802315105
M3 - Journal article
C2 - 18541911
VL - 105
SP - 8327
EP - 8332
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 24
ER -