@article{9f1b7d5df7f74052bd490b0aef793b04,
title = "Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells",
abstract = "In chronic liver injury, quiescent hepatic stellate cells change into proliferative myofibroblast-like cells, which are a main source of fibrosis. We have recently reported that these cells synthesize ADAM12, a disintegrin and metalloprotease whose expression is up-regulated by TGF-beta1 in liver cancers. Here, we studied the role of the serine/threonine p70S6 kinase (p70S6K) in regulating TGF-beta1-induced ADAM12 expression.",
keywords = "ADAM Proteins, Cells, Cultured, Gene Expression, Humans, Liver, MAP Kinase Kinase Kinases, Membrane Proteins, Phosphatidylinositol 3-Kinases, Ribosomal Protein S6 Kinases, 70-kDa, Signal Transduction, Transforming Growth Factor beta, Transforming Growth Factor beta1",
author = "{Le Pabic}, H{\'e}l{\`e}ne and Annie L'Helgoualc'h and Alexandre Coutant and Wewer, {Ulla M} and Georges Baffet and Bruno Cl{\'e}ment and Nathalie Th{\'e}ret",
year = "2005",
month = dec,
day = "1",
doi = "10.1016/j.jhep.2005.05.025",
language = "English",
volume = "43",
pages = "1038--44",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "6",
}