Is maternal weight gain between pregnancies associated with risk of large-for-gestational age birth? Analysis of a UK population-based cohort

Objective Maternal overweight and obesity during pregnancy increases the risk of large-for-gestational age (LGA) birth and childhood obesity. We aimed to investigate the association between maternal weight change between subsequent pregnancies and risk of having a LGA birth. Design Population-based cohort. Setting Routinely collected antenatal healthcare data between January 2003 and September 2017 at University Hospital Southampton, England. Participants Health records of women with their first two consecutive singleton live-birth pregnancies were analysed (n=15 940). Primary outcome measure Risk of LGA, recurrent LGA and new LGA births in the second pregnancy. Results Of the 15 940 women, 16.0% lost and 47.7% gained weight (≥1 kg/m 2) between pregnancies. A lower proportion of babies born to women who lost ≥1 kg/m 2 (12.4%) and remained weight stable between-1 and 1 kg/m 2 (11.9%) between pregnancies were LGA compared with 13.5% and 15.9% in women who gained 1-3 and ≥3 kg/m 2, respectively. The highest proportion was in obese women who gained ≥3 kg/m 2 (21.2%). Overweight women had a reduced risk of recurrent LGA in the second pregnancy if they lost ≥1 kg/m 2 (adjusted relative risk (aRR) 0.69, 95% CI 0.48 to 0.97) whereas overweight women who gained ≥3 kg/m 2 were at increased risk of new LGA after having a non-LGA birth in their first pregnancy (aRR 1.35, 95% CI 1.05 to 1.75). Normal-weight women who gained weight were also at increased risk of new LGA in the second pregnancy (aRR 1.26, 95% CI 1.06 to 1.50 with gain of 1-3 kg/m 2 and aRR 1.34, 95% CI 1.09 to 1.65 with gain of ≥3 kg/m 2). Conclusions Losing weight after an LGA birth was associated with a reduced LGA risk in the next pregnancy in overweight women, while interpregnancy weight gain was associated with an increased new LGA risk. Preventing weight gain between pregnancies is an important measure to achieve better maternal and offspring outcomes.