Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Diabetes |
| Vol/bind | 54 |
| Udgave nummer | 4 |
| Sider (fra-til) | 1245-8 |
| Antal sider | 3 |
| ISSN | 0012-1797 |
| Status | Udgivet - 2005 |
Bibliografisk note
Keywords: Adolescent; Age of Onset; Child; Cohort Studies; Diabetes Mellitus, Type 1; Estrogens; Female; Genotype; Humans; Interleukin-6; Male; Polymorphism, Single Nucleotide; Puberty; Sex FactorsCitationsformater
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Is puberty an accelerator of type 1 diabetes in IL6-174CC females? / Gillespie, Kathleen M; Nolsøe, Runa; Betin, Virginie M; Kristiansen, Ole P; Bingley, Polly J; Mandrup-Poulsen, Thomas; Gale, Edwin A M.
I: Diabetes, Bind 54, Nr. 4, 2005, s. 1245-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Is puberty an accelerator of type 1 diabetes in IL6-174CC females?
AU - Gillespie, Kathleen M
AU - Nolsøe, Runa
AU - Betin, Virginie M
AU - Kristiansen, Ole P
AU - Bingley, Polly J
AU - Mandrup-Poulsen, Thomas
AU - Gale, Edwin A M
N1 - Keywords: Adolescent; Age of Onset; Child; Cohort Studies; Diabetes Mellitus, Type 1; Estrogens; Female; Genotype; Humans; Interleukin-6; Male; Polymorphism, Single Nucleotide; Puberty; Sex Factors
PY - 2005
Y1 - 2005
N2 - The pubertal peak in onset of type 1 diabetes occurs earlier in girls than boys. We postulated that this sex difference might be mediated in part by estrogen or by genes regulated by estrogen, such as the interleukin-6 (IL6) gene. Previous studies concerning the role of an estrogen-sensitive single nucleotide polymorphism (SNP) in the IL6 promoter in type 1 diabetes have proved contradictory. We therefore selected a large, genetically homogenous population-based cohort, analyzed by age at onset and sex, to test the hypothesis that the IL6-174G>C SNP affects age at onset of type 1 diabetes in females but not in males. We found that the IL6-174CC genotype was significantly less frequent in females diagnosed after than in those diagnosed before the age of 10 years (19 vs. 13%, P = 0.016). No genotype difference was observed in males stratified for age at onset. Among children diagnosed after age 10, the median age of onset was 11.9 years (intraquartile range 10.7-14.6) in 34 girls homozygous for IL6-174C compared with 13.2 years (11.6-15.4) in 229 girls with other genotypes and 13.5 years (12.0-15.6) in 339 males with any IL6-174 genotype (P = 0.012). These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter.
AB - The pubertal peak in onset of type 1 diabetes occurs earlier in girls than boys. We postulated that this sex difference might be mediated in part by estrogen or by genes regulated by estrogen, such as the interleukin-6 (IL6) gene. Previous studies concerning the role of an estrogen-sensitive single nucleotide polymorphism (SNP) in the IL6 promoter in type 1 diabetes have proved contradictory. We therefore selected a large, genetically homogenous population-based cohort, analyzed by age at onset and sex, to test the hypothesis that the IL6-174G>C SNP affects age at onset of type 1 diabetes in females but not in males. We found that the IL6-174CC genotype was significantly less frequent in females diagnosed after than in those diagnosed before the age of 10 years (19 vs. 13%, P = 0.016). No genotype difference was observed in males stratified for age at onset. Among children diagnosed after age 10, the median age of onset was 11.9 years (intraquartile range 10.7-14.6) in 34 girls homozygous for IL6-174C compared with 13.2 years (11.6-15.4) in 229 girls with other genotypes and 13.5 years (12.0-15.6) in 339 males with any IL6-174 genotype (P = 0.012). These data support the hypothesis that pubertal changes may contribute to accelerated onset of type 1 diabetes in genetically susceptible females. This phenomenon may be orchestrated by the action of estrogen on the IL6 promoter.
M3 - Journal article
C2 - 15793269
VL - 54
SP - 1245
EP - 1248
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 4
ER -