Abstract
In pregnancies of women with obesity or diabetes, neonates are often overgrown. Thus, the pregnancy period in these women offers a window of opportunity to reduce childhood obesity by preventing neonatal overgrowth. However, the focus has been almost exclusively on growth in late pregnancy. This perspective article addresses possible growth deviations earlier in pregnancy and their potential contribution to neonatal overgrowth. This narrative review focuses on six large-scale, longitudinal studies that included ∼14,400 pregnant women with at least three measurements of fetal growth. A biphasic pattern in growth deviation, including growth reduction in early pregnancy followed by overgrowth in late pregnancy, was found in fetuses of women with obesity, gestational diabetes mellitus (GDM), or type 1 diabetes compared with lean women and those with normal glucose tolerance. Fetuses of women with these conditions have reduced abdominal circumference (AC) and head circumference (HC) in early pregnancy (observed between 14 and 16 gestational weeks), while later in pregnancy they present the overgrown phenotype with larger AC and HC (from approximately 30 gestational weeks onwards). Fetuses with early-pregnancy growth reduction who end up overgrown presumably have undergone in utero catch-up growth. Similar to postnatal catch-up growth, this may confer a higher risk of obesity in later life. Potential long-term health consequences of early fetal growth reduction followed by in utero catch-up growth need to be explored.
Originalsprog | Engelsk |
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Tidsskrift | Diabetes Care |
Vol/bind | 46 |
Udgave nummer | 6 |
Sider (fra-til) | 1124-1131 |
Antal sider | 8 |
ISSN | 0149-5992 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:Funding. G.D. was supported by a visiting professorship grant from the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation, grant number NNF17SA0031406. He also received funds from the O€sterreichische Nationalbank (Anniversary Fund, project number 17950). Duality of Interest. C.Z. is an editorial board member of Diabetes Care. No other potential conflicts of interest relevant to this article were reported.
Publisher Copyright:
© 2023, American Diabetes Association Inc.. All rights reserved.